ArticleASN neuro2026
Microstructural Features Linking White Matter and Mathematics in Adolescence.
Article in ASN neuro, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mathematics is a complex skill requiring the coordination of distributed gray matter brain regions connected by white matter tracts. Diffusion tensor imaging (DTI) studies have revealed a network of white matter tracts that support math processing, but the specific microstructural features driving this relationship remain unclear. Other magnetic resonance imaging (MRI) methods-neurite orientation dispersion and density imaging (NODDI), inhomogeneous magnetization transfer (ihMT), multicomponent driven-equilibrium single-pulse observation of T1 and T2 (mcDESPOT), and g-ratio imaging-can probe microstructural features like axon packing, fiber orientation, and myelin more specifically than DTI. We applied these methods alongside DTI to evaluate links between white matter microstructure and math in a longitudinal cohort of 33 6-16 year olds (66 datasets total). Partial correlations between metrics of white matter microstructure and math skill, controlling for age and gender, were carried out in the left superior longitudinal and inferior longitudinal fasciculi, corticospinal tract, and the splenium. Cross-sectionally, fiber coherence of the corticospinal tract and superior longitudinal fasciculus correlated to mathematics performance. Longitudinally, change in markers of axonal packing and myelin were linked to changes in both math skill and fluency in a regionally-specific manner, with links to myelin-sensitive metrics most prevalent. Notably, decreases in myelin were linked to improvements in mathematics over time, suggesting ongoing refinement of the math network. Findings presented here did not survive multiple comparisons corrections, but provide insight for future work elaborating upon these associations in larger samples.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.