Comprehensive Evaluation of Safety, Functional Properties, and Immunomodulatory Activity of 19 Probiotic Strains Approved by the Ministry of Food and Drug Safety (MFDS).

Yeonju Kim, Soeun Lee, Seonju Kim, Minyeong Jung, Jieun Jung, Ju-Hoon Lee, Jaewoo Bai

Abstract read

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Article in Journal of microbiology and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Yeonju KimDepartment of Food Science and Biotechnology, Seoul Women's University, Seoul 01797, Republic of Korea.

Soeun LeeDepartment of Food Science and Biotechnology, Seoul Women's University, Seoul 01797, Republic of Korea.

Seonju KimDepartment of Food Science and Biotechnology, Seoul Women's University, Seoul 01797, Republic of Korea.

Minyeong JungDepartment of Food Science and Biotechnology, Seoul Women's University, Seoul 01797, Republic of Korea.

Jieun JungDepartment of Food Science and Biotechnology, Seoul Women's University, Seoul 01797, Republic of Korea.

Ju-Hoon LeeDepartment of Agricultural Biotechnology, Seoul National University, Seoul 08826, Republic of Korea.

Jaewoo BaiDepartment of Food Science and Biotechnology, Seoul Women's University, Seoul 01797, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Ministry of Food and Drug Safety (MFDS) has approved 19 probiotic strains for use as functional food ingredients. Although the characteristics of individual strains have been previously reported, a comprehensive evaluation of all 19 MFDS-approved probiotic strains under a unified experimental framework has not yet been conducted. Therefore, this study systematically assessed the safety, probiotic properties, and immunomodulatory activity of the 19 MFDS-approved strains. Cytotoxicity, bile salt hydrolase (BSH) activity, D-lactate production, tolerance to simulated gastrointestinal tract (GIT) conditions, adhesion capacity, and immunomodulatory activity were evaluated. All strains showed no cytotoxicity toward Caco-2 cells. BSH activity was detected in 14 strains, whereas D-lactate production (1.14-28.88 mM) was observed only in Lactobacillaceae strains. The strains exhibited a broad range of GIT tolerance, with survival rates ranging from 23.55% to 95.58%.

Indexed as

Immunologic FactorsProbioticsAmidohydrolasesAnimalsBacterial AdhesionBifidobacteriumCaco-2 CellsFood SafetyGastrointestinal TractHumansLactic AcidLactobacillusMiceRAW 264.7 CellsAmidohydrolasescholoylglycine hydrolaseImmunologic FactorsLactic AcidApproved probiotic strainImmunomodulatory activityProbiotic propertySafety

Identifiers

PMID42581439

DOI10.4014/jmb.2605.05037

PMCPMC13462606

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