ArticleAmerican journal of physiology. Renal physiology2026
Perilipin 2 drives cisplatin-induced acute kidney injury in young but not aged kidneys.
Saiya Zhu, Chen Dai, Kelly Zheng, Yuan Gui, Jia-Jun Liu, Jianzhong Li, Yanbao Yu, Silvia Liu, Dong Zhou
Abstract read
In one paragraphArticle in American journal of physiology. Renal physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Saiya ZhuDivision of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut, United States.
Chen DaiDivision of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut, United States.ORCID 0009-0009-8690-1208 Kelly ZhengDivision of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut, United States.ORCID 0009-0002-3288-371X Yuan GuiDivision of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut, United States.
Jia-Jun LiuOrgan Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.
Jianzhong LiDivision of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut, United States.
Yanbao YuDepartment of Chemistry & Biochemistry, University of Delaware, Newark, Delaware, United States.ORCID 0000-0003-2994-1974 Silvia LiuOrgan Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.ORCID 0000-0002-1840-9520 Dong ZhouDivision of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut, United States.ORCID 0000-0003-1981-8745 Funding
Importance of cell-matrix interactions in kidney repair after acute kidney injuryR01DK132059 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Dong Zhou · 2023 to 2026
$1.9MEarly and Transient Activation of Fibroblasts Promotes Tubule Repair after Acute Kidney InjuryK01DK116816 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZHOU, DONG · 2019 to 2021
$509kThe formation of kidney local microenvironment after acute kidney injury.R03DK128529 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI ZHOU, DONG · 2021 to 2022
$246kAmerican Heart Association (AHA) 25CDA1435759HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK116816NIDDK NIH HHS K01 DK116816NIDDK NIH HHS R01 DK132059NIDDK NIH HHS R03 DK128529
6 · The paper itselfAbstract
Cisplatin is a widely used chemotherapeutic agent, but acute kidney injury (AKI) remains its dose-limiting toxicity, particularly in older patients. In recent years, dysregulated lipid metabolism has emerged as a key driver of cisplatin nephrotoxicity; however, the underlying mechanisms and their modulation across ages remain incompletely understood. Here, we demonstrated that the lipid droplet protein perilipin 2 (Plin2) was induced after cisplatin-induced AKI, with markedly greater induction in aged kidneys and distinct organ-specific patterns in the liver and heart. Knockdown of
Indexed as
Acute Kidney InjuryAgingAntineoplastic AgentsCisplatinKidneyPerilipin-2Age FactorsAnimalsApoptosisDisease Models, AnimalMaleMiceMice, Inbred C57BLAntineoplastic AgentsCisplatinPerilipin-2Plin2 protein, mouseacute kidney injurycisplatinHmgcs2perilipin 2Sirt5
Identifiers
PMID42581421
PMCPMC13541002
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