Evidence map›Paper›PMID 42581384›Full record

Trial reportThe Journal of physiology2026

Increasing gut short-chain fatty acids protects intestinal barrier function but does not spare muscle glycogen or impact aerobic performance.

J Philip Karl, Heather S Fagnant, Christopher T Carrigan, Lee M Margolis

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

J Philip KarlMilitary Nutrition Division, U.S. Army Research Institute of Environmental Medicine, 10 General Greene Ave, Natick, Massachusetts, USA.ORCID https://orcid.org/0000-0002-5871-2241
Heather S FagnantMilitary Nutrition Division, U.S. Army Research Institute of Environmental Medicine, 10 General Greene Ave, Natick, Massachusetts, USA.
Christopher T CarriganMilitary Nutrition Division, U.S. Army Research Institute of Environmental Medicine, 10 General Greene Ave, Natick, Massachusetts, USA.
Lee M MargolisMilitary Nutrition Division, U.S. Army Research Institute of Environmental Medicine, 10 General Greene Ave, Natick, Massachusetts, USA.

Funding

U.S. Army Medical Research and Development Command MO220066
6 · The paper itself

Abstract

Animal studies suggest gut microbiota-derived short-chain fatty acids (SCFA) provide an intestinal barrier-protecting, glycogen-sparing energy source that increases aerobic endurance performance, but confirmation in humans is needed. This study aimed to determine whether increasing colonic SCFA availability impacts intestinal barrier function, substrate metabolism, muscle glycogen and aerobic performance in healthy adults. Using a randomized, double-blind, crossover design 12 active men (age 18-30 years;

Indexed as

ExerciseFatty Acids, VolatileGlycogenIntestinal Barrier FunctionMuscle, SkeletalAdolescentAdultCross-Over StudiesDouble-Blind MethodGastrointestinal MicrobiomeHumansMaleYoung AdultFatty Acids, VolatileGlycogenbioenergeticsdietary supplementenergy metabolismfibregut healthgut microbiomephysical activity

Identifiers

PMID42581384
PMCPMC13532992

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.