ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Sleep apnea in REM sleep as an amplifier of vascular contributions to Alzheimer's disease.
Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Obstructive sleep apnea (OSA), a common though underdiagnosed disorder in older adults, represents a potential upstream vascular stressor linked to increased Alzheimer's disease (AD) risk. In this Perspective article, we propose a stage-informed framework in which rapid eye movement (REM) sleep-related respiratory events amplify vascular contributions to AD. This framework is unified across four linked lines of evidence suggesting that (1) REM sleep physiology magnifies the hypoxic and hemodynamic burden of OSA, (2) the cardiometabolic consequences of sleep apnea are heightened in REM sleep, (3) REM-related hypoxemia is associated with markers of cerebrovascular pathology, and (4) vascular effects associated with REM-related hypoxemia are associated with medial temporal lobe vulnerability and memory dysfunction: core features of AD. Although direct evidence linking REM-specific OSA to AD biomarkers is lacking, we highlight REM sleep as a potentially critical window through which sleep-disordered breathing may amplify vascular contributions to AD.
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