Evidence map›Paper›PMID 42581181›Full record

ArticleMikrochimica acta2026

Magnetic core-satellite SERS biosensor for ultrasensitive quantification of squamous cell carcinoma antigen in human serum.

Hongping Xiao, Xinying Wang, Siqi Xue, Zhongyuan Wu, Rongjun Huang, Min Fan, Yuanmei Chen, Shangyuan Feng

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hongping XiaoKey Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, 350117, China.
Xinying WangCollege of Chemistry, Fuzhou University, Fuzhou, 350108, China.
Siqi XueDepartment of Anesthesiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.
Zhongyuan WuKey Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, 350117, China.
Rongjun HuangKey Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, 350117, China.
Min FanFujian Provincial Key Laboratory for Advanced Micro-nano Photonics Technology and Devices, Institute for Photonics Technology, Quanzhou Normal University, Quanzhou, 362000, China. fanmin@qztc.edu.cn.
Yuanmei ChenClinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350014, China. chenym091@hotmail.com.
Shangyuan FengFujian Provincial Key Laboratory for Advanced Micro-nano Photonics Technology and Devices, Institute for Photonics Technology, Quanzhou Normal University, Quanzhou, 362000, China. syfeng@qztc.edu.cn.

Funding

Fujian Provincial Education and Scientific Research Project for Young and Middle-aged Teachers JAT241093Fujian Provincial Natural Science Foundation of China 2025J01968Fuzhou Science and Technology Major Project 2023-ZD-004Joint Funds for the Innovation of Science and Technology 2023Y9410, 2024Y9597Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0529400, 2024ZD0529406
6 · The paper itself

Abstract

Squamous cell carcinoma antigen (SCCA) a magnetic enrichment-assisted core-satellite surface-enhanced Raman scattering (SERS) biosensor for ultrasensitive squamous cell carcinoma antigen (SCCA) detection is reported. Magnetic nanoparticles functionalized with SCCA capture antibodies act as enrichment cores, while 4-mercaptobenzoic acid (MBA)-encoded Au@Ag core-shell nanoparticles conjugated with SCCA detection antibodies serve as SERS satellites. Target-mediated sandwich immunorecognition induces a dynamically assembled core-satellite structure, bringing plasmonic nanogaps into close proximity and generating reproducible electromagnetic hot spots for signal amplification. Magnetic pre-enrichment and controlled assembly help reduce nonspecific protein interference in serum and contribute to stable signal generation. The biosensor exhibited a monotonic concentration-dependent Raman response over the range of 1 fg/mL to 10¹¹ fg/mL and achieved a limit of detection (LOD) of 60.0 fg/mL. Quantitative determination of serum samples was performed using an independently established matrix-matched calibration curve. The platform was further validated using real human serum samples from early-stage lung SqCC patients (n = 8) and healthy controls (n = 8), showing higher SCCA concentrations in patient samples than in healthy controls and clear discrimination between the two groups. Overall, the proposed magnetic enrichment-assisted core-satellite SERS immunoassay provides a robust analytical strategy for sensitive SCCA quantification in complex serum matrices.

Indexed as

Antigens, NeoplasmBiosensing TechniquesMagnetite NanoparticlesSerpinsSpectrum Analysis, RamanAntibodies, ImmobilizedBenzoatesGoldHumansImmunoassayLimit of DetectionMetal NanoparticlesSilverSulfhydryl Compounds4-mercaptobenzoateAntibodies, ImmobilizedAntigens, NeoplasmBenzoatesGoldMagnetite NanoparticlesSerpinsSilversquamous cell carcinoma-related antigenSulfhydryl CompoundsCore–satellite nanoassemblyImmunoassayMagnetic enrichmentSquamous cell carcinoma antigenSurface-enhanced Raman scattering

Identifiers

PMID42581181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.