Evidence map›Paper›PMID 42580929›Full record

ArticleDiagnostic and interventional imaging2026

Association between low bone mineral density and subchondral insufficiency fractures of the knee in women, and influence of radial meniscal root tears.

Mohamad Z Alzaher, Wasim Issa, Tuhina Neogi, Ambrose J Huang, Jad S Husseini, William E Palmer, Jamie Collins, S Reza Jafarzadeh, Theresa S Patzer, C Kent Kwoh and 2 more

Abstract read
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In one paragraph

Article in Diagnostic and interventional imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mohamad Z AlzaherDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Wasim IssaDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Tuhina NeogiSection of Rheumatology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02115, USA.
Ambrose J HuangDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Jad S HusseiniDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
William E PalmerDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Jamie CollinsOrthopaedic and Arthritis Center for Outcomes Research (OrACORe), Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
S Reza JafarzadehSection of Rheumatology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02115, USA; Department of Emergency Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.
Theresa S PatzerDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg 97080, Germany.
C Kent KwohUniversity of Arizona Arthritis Center, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Ali GuermaziQuantitative Imaging Center, Department of Radiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02115, USA.
Mohamed JarrayaDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: mjarraya@mgh.harvard.edu.

Funding

Research and Evaluation Support Core Unit (RESCU Core)P30AR072571 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Michael Paul Lavalley · 2019 to 2026
$6.9M
The Role of Urate in Knee Osteoarthritis-Related Inflammation, Pathology and PainK24AR070892 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2017 to 2026
$1.1M
Unraveling the discordance between structural damage and pain phenotypes in knee osteoarthritisK23AR084603 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI Mohamed Jarraya · 2024 to 2026
$525k
Bayesian approaches to identify persons with osteoarthritis in electronic health records and administrative health data in the absence of a perfect reference standardR21AR081442 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI JAFARZADEH, S. REZA · 2023 to 2023
$254k
NIAMS NIH HHS K23 AR084603NIAMS NIH HHS K24 AR070892NIAMS NIH HHS P30 AR072571NIAMS NIH HHS R21 AR081442
6 · The paper itself

Abstract

purposeThe purpose of this study was to evaluate the association between systemic low bone mineral density (BMD) and subchondral insufficiency fracture (SIF) of the knee in women, and to explore whether this association is modified by radial meniscal tears. MATERIALS AND

methodsIn this case-control study, women with and without MRI-confirmed SIF who had available dual-energy X-ray absorptiometry T-score measurements were included. Systemic BMD was categorized using T-scores. Multivariable logistic regression models with BMD as the exposure and SIF as the outcome, adjusting for age and body mass index were fitted. An exploratory stratified analysis to assess potential effect modification by meniscal radial tear status was also conducted.

resultsA total of 121 women with SIF (mean age, 69.1 ± 7.5 [standard deviation] years) and 124 controls (70.4 ± 8.3 [standard deviation] years) were analyzed. After adjustment, osteoporosis was associated with higher odds of SIF (odds ratio [OR], 2.29; 95% confidence interval [CI]: 1.03-5.09), whereas osteopenia (OR, 1.33; 95% CI: 0.69-2.55) showed no significant association. In exploratory stratified analysis to test for effect modification, there were no significant interactions between low BMD and radial root tears (P-interaction = 0.178). However, small strata likely limited the power to detect a significant effect modification, as evidenced by overlapping wide 95% CIs.

conclusionOsteoporosis is associated with higher odds of SIF of the knee in women, while osteopenia is not.

Indexed as

Bone mineral densityMagnetic resonance imagingMeniscal tearOsteoporosisOsteropeniaSubchondral insufficiency fracture

Identifiers

PMID42580929
PMCPMC13492403

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.