Evidence map›Paper›PMID 42580773›Full record

ArticleBMJ open respiratory research2026

Disease burden of viral respiratory infections in people with intellectual disabilities: a scoping review.

Lynette J van Susante-Oost, Mathilde Mastebroek, Monique C J Koks-Leensen, Aura Timen, Geraline L Leusink, Maarten Cuypers

Abstract readScoping Review
In one paragraph

Article in BMJ open respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lynette J van Susante-Oost *Department of Primary and Community Care, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-7566-5021
Mathilde Mastebroek *Department of Primary and Community Care, Radboud University Medical Center, Nijmegen, The Netherlands.
Monique C J Koks-LeensenDepartment of Primary and Community Care, Radboud University Medical Center, Nijmegen, The Netherlands.
Aura TimenDepartment of Primary and Community Care, Radboud University Medical Center, Nijmegen, The Netherlands.
Geraline L LeusinkDepartment of Primary and Community Care, Radboud University Medical Center, Nijmegen, The Netherlands.
Maarten CuypersDepartment of Primary and Community Care, Radboud University Medical Center, Nijmegen, The Netherlands maarten.cuypers@radboudumc.nl.ORCID http://orcid.org/0000-0003-1715-4375

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundViral respiratory infections are highly contagious and associated with an increased risk of serious adverse health outcomes in vulnerable populations, including people with intellectual disabilities. However, little is known about the overall disease burden of viral respiratory infections among people with intellectual disabilities.

aimThis scoping review aims to provide an overview of the existing literature on the disease burden of viral respiratory infections among people with intellectual disabilities.

methodsStudies published between 1999 and 10 July 2024, were identified through PubMed, MEDLINE, Embase and Web of Science, and included if focused on adults with intellectual disabilities, viral respiratory infections and relevant health outcomes such as infection rate, mortality, hospitalisation, functional impairments or quality of life.

results58 articles were included, of which the majority focused on COVID-19 (42/58) or influenza (13/58). Studies varied in their methodology and outcome measures. Evidence on COVID-19 and influenza showed that people with intellectual disabilities experience a higher disease burden from these infections compared with the general population. Particularly disproportionate effects were evident among people with Down syndrome, who had higher mortality estimates and an increased burden of comorbidities associated with severe disease and death.

conclusionAlthough available evidence appeared limited and diverse, this scoping review shows a higher disease burden in people with intellectual disabilities, in particular for COVID-19 and influenza-type viruses, which can be indicative of the impact of other viral respiratory infections as well. This highlights the importance of measures to prevent and control the spread of respiratory pathogens among this group.

Indexed as

Cost of IllnessCOVID-19Influenza, HumanIntellectual DisabilityRespiratory Tract InfectionsComorbidityHumansQuality of LifeSARS-CoV-2COVID-19Respiratory InfectionViral infection

Identifiers

PMID42580773
PMCPMC13475619

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.