Evidence map›Paper›PMID 42580674›Full record

ArticleInternational journal of epidemiology2026

Colorectal cancer incidence and survival trends in Uganda: a population-based registry analysis (2000-20).

Nicholas Matovu, Helen G Coleman, Gerald Mutungi, Michael Donnelly, Brian T Johnston, Maurice B Loughrey, Finian J Bannon, Charlene M McShane

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Article in International journal of epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Nicholas MatovuCentre for Public Health, Queen's University Belfast, Belfast, United Kingdom.ORCID 0000-0003-4756-288X
Helen G ColemanCentre for Public Health, Queen's University Belfast, Belfast, United Kingdom.ORCID 0000-0003-4872-7877
Gerald MutungiDepartment of Non-Communicable Diseases, Ministry of Health, Kampala, Uganda.
Michael DonnellyCentre for Public Health, Queen's University Belfast, Belfast, United Kingdom.ORCID 0000-0001-8380-7413
Brian T JohnstonDeartment of Gastroenterology, Belfast Health and Social Care Trust, Belfast, United Kingdom.
Maurice B LoughreyCentre for Public Health, Queen's University Belfast, Belfast, United Kingdom.ORCID 0000-0001-8424-1765
Finian J BannonCentre for Public Health, Queen's University Belfast, Belfast, United Kingdom.
Charlene M McShaneCentre for Public Health, Queen's University Belfast, Belfast, United Kingdom.ORCID 0000-0001-8609-0788

Funding

British Society of GastroenterologyQueen's University Belfast International PhD
6 · The paper itself

Abstract

introductionThe epidemiology of colorectal cancer (CRC) in Uganda is not sufficiently described, with the limited available data suggesting an increasing incidence. This study assessed CRC incidence and survival trends by using data from the two major population-based cancer registries in Uganda.

methodsWe extracted incident CRC cases (ICD C18-C20) from the Kampala Cancer Registry (KCR; 2000-19) and the Gulu Cancer Registry (GCR; 2015-20). Crude and age-standardized incidence rates (ASIRs) and 1-, 3-, and 5-year survival estimates were calculated by using SEER*Stat software. Kaplan-Meier methods were applied to generate survival curves, with subgroup differences assessed by using log-rank tests. Joinpoint regression was used to evaluate trends in the incidence rates.

resultsA total of 1118 CRC cases were identified. The mean age at diagnosis was 54.3 years (16.2 SD), with 37.8% diagnosed before age 50 years. The incidence was higher in the KCR compared with the GCR (crude: 2.4 vs. 0.8; ASIR: 9.2 vs. 2.0 per 100 000). A significant rise in ASIRs occurred exclusively among males in the KCR, with a 2.1% annual increase over 20 years (P < .001). In a sensitivity analysis restricted to histologically confirmed cases, the 1-, 3-, and 5-year relative survival in the KCR was 52.7%, 14.5%, and 4.3%, respectively.

conclusionCRC incidence in Uganda remains low but is increasing among males. Four in 10 cases are diagnosed before age 50 years, suggesting a substantial burden of early-onset disease. Survival outcomes remain poor, stressing the need for strengthened prevention, early detection, and treatment services.

Indexed as

Colorectal NeoplasmsAdultAgedAged, 80 and overAge DistributionFemaleHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedRegistriesSex DistributionUgandaYoung Adultcancer epidemiologycolorectal cancerincidencesurvivaltrendsUganda

Identifiers

PMID42580674
PMCPMC13461188

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.