Evidence map›Paper›PMID 42580622›Full record

ArticleNeuroscience letters2026

Conditional deletion of Bmal1 modestly alters acute pathology without affecting functional recovery after contusive spinal cord injury.

Lukasz P Slomnicki, Christine D Armstrong, Johnny R Morehouse, Kariena Andres, Erik S Musiek, Sujata Saraswat Ohri, Michal Hetman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lukasz P SlomnickiKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA.
Christine D ArmstrongKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA.
Johnny R MorehouseKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA.
Kariena AndresKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA.
Erik S MusiekDepartment of Neurology, Washington University, St. Louis, MO, USA.
Sujata Saraswat OhriKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA; Department of Neurological Surgery, University of Louisville, Louisville, KY, USA.
Michal HetmanKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, USA; Department of Neurological Surgery, University of Louisville, Louisville, KY, USA; Department of Anatomical Sciences & Neurobiology, University of Louisville, Louisville, KY, USA; Department of Pharmacology & Toxicology, University of Louisville, Louisville, KY, USA. Electronic address: michal.hetman@louisville.edu.

Funding

BMAL1/ARNTL plays a critical, non-circadian role in secondary tissue damage after contusive SCIR01NS114404 · NINDS · UNIVERSITY OF LOUISVILLE · PI HETMAN, MICHAL, SARASWAT, SUJATA OHRI · 2020 to 2024
$2.6M
NINDS NIH HHS R01 NS114404
6 · The paper itself

Abstract

Germline deletion of the core circadian transcription factor Bmal1 has been shown to reduce blood-spinal cord barrier (BSCB) disruption and tissue loss following moderate T9 contusive spinal cord injury (SCI) in mice. Therefore, effects of conditional Bmal1 deletions were tested using the same model. A strong reduction of Bmal1 expression in the brain or spinal cord followed tamoxifen treatment of Bmal1

Indexed as

ARNTL Transcription FactorsRecovery of FunctionSpinal Cord InjuriesAnimalsBrainFemaleGene DeletionMiceMice, KnockoutSpinal CordARNTL Transcription FactorsBmal1 protein, mouseBlood-spinal cord barrierBMAL1Circadian rhythmsContusive spinal cord injuryHindlimb recoveryNeuroinflammationNeurotrauma

Identifiers

PMID42580622
PMCPMC13526234

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.