Evidence map›Paper›PMID 42580337›Full record

ArticleCell2026

Convergent evolution of metabolic regulation governs redox adaptation in Toxoplasma.

Christopher J Giuliano, Chinmay A Kalluraya, Joachim Kloehn, Megan A Sloan, Molly E Bunkofske, Christopher A Hunter, Dominique Soldati-Favre, Clare R Harding, Sebastian Lourido

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christopher J GiulianoWhitehead Institute, Cambridge, MA, USA; Biology Department, MIT, Cambridge, MA, USA.
Chinmay A KallurayaWhitehead Institute, Cambridge, MA, USA; Biology Department, MIT, Cambridge, MA, USA.
Joachim KloehnDepartment of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland.
Megan A SloanCentre of Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK.
Molly E BunkofskeDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Christopher A HunterDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Dominique Soldati-FavreDepartment of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland.
Clare R HardingCentre of Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK.
Sebastian LouridoWhitehead Institute, Cambridge, MA, USA; Biology Department, MIT, Cambridge, MA, USA. Electronic address: lourido@wi.mit.edu.

Funding

Development and maintenance of chronic toxoplasmosisR01AI158501 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI LOURIDO, SEBASTIAN · 2021 to 2025
$3.3M
Control of parasite invasion by a microneme protein complex conserved in ApicomplexansR01AI144369 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI LOURIDO, SEBASTIAN · 2020 to 2024
$2.4M
NIAID NIH HHS R01 AI144369NIAID NIH HHS R01 AI158501Wellcome Trust
6 · The paper itself

Abstract

Diverse organisms adjust metabolic gene expression during crowding as they encounter nutrient scarcity, oxidative stress, and waste accumulation. Apicomplexan parasites experience these stresses during intracellular growth within host cells yet lack known regulators of metabolic adaptation. We screened the apicomplexan parasite Toxoplasma gondii to identify genes that support parasite fitness during crowding. Nicotinamide adenine dinucleotide (NAD)(P)

Indexed as

ToxoplasmaAdaptation, PhysiologicalAnimalsEvolution, MolecularIron-Sulfur ProteinsOxidation-ReductionOxidative StressProtozoan ProteinsReactive Oxygen SpeciesRNA-Binding ProteinsIron-Sulfur ProteinsProtozoan ProteinsReactive Oxygen SpeciesRNA-Binding Proteinsapicomplexanconvergent evolutionironiron-sulfur clustermetabolic regulationoxidative stressparasitologyRNA-binding proteinToxoplasma gondii

Identifiers

PMID42580337
PMCPMC13531851

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.