Evidence map›Paper›PMID 42579840›Full record

Observational studyNeurology(R) neuroimmunology & neuroinflammation2026

Gianmarco Abbadessa, Ugo Chianese, Claudia Russo, Giuseppina Miele, Elisabetta Maida, Gianmarco Esposito, Giuseppe Romano, Floriana Bile, Elisabetta Signoriello, Giacomo Lus and 7 more

Abstract readObservational Study
In one paragraph

Observational study in Neurology(R) neuroimmunology & neuroinflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Gianmarco AbbadessaDipartimento di Scienze Mediche e Chirurgiche Avanzate, Università della Campania Luigi Vanvitelli, Napoli, Italia.ORCID 0000-0001-8912-3055
Ugo ChianeseDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. de Crecchio 7, Naples, Italy.ORCID 0000-0003-2726-1895
Claudia RussoDipartimento di Medicina di Laboratorio e Trasfusionale, Azienda Ospedaliera Universitaria Federico II, Napoli, Italy.ORCID 0000-0001-5869-4445
Giuseppina MieleUOSD Neurologia II, AOU Vanvitelli, Naples, Italy.
Elisabetta MaidaDipartimento di Scienze Mediche e Chirurgiche Avanzate, Università della Campania Luigi Vanvitelli, Napoli, Italia.ORCID 0009-0003-6505-0834
Gianmarco EspositoLaboratorio di Immunologia, Istituto degli Endotipi in Oncologia, Metabolismo e Immunologia "G. Salvatore" - Consiglio Nazionale delle Ricerche (IEOMI-CNR), Napoli, Italy.ORCID 0009-0002-9649-9418
Giuseppe RomanoDipartimento di Scienze Mediche e Chirurgiche Avanzate, Università della Campania Luigi Vanvitelli, Napoli, Italia.ORCID 0000-0001-7181-5627
Floriana BileDipartimento di Scienze Mediche e Chirurgiche Avanzate, Università della Campania Luigi Vanvitelli, Napoli, Italia.
Elisabetta SignorielloUOSD Neurologia II, AOU Vanvitelli, Naples, Italy.ORCID 0000-0001-5753-6752
Giacomo LusDipartimento di Scienze Mediche e Chirurgiche Avanzate, Università della Campania Luigi Vanvitelli, Napoli, Italia.ORCID 0000-0002-9457-1124
Luigi LavorgnaUOC Neurologia I, AOU Vanvitelli, Naples, Italy.ORCID 0000-0003-4625-4236
Richard S NicholasDepartment of Brain Sciences, Imperial College London, United Kingdom.ORCID 0000-0003-0414-1225
Lucia AltucciDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. de Crecchio 7, Naples, Italy.ORCID 0000-0002-7312-5387
Claudio ProcacciniLaboratorio di Immunologia, Istituto degli Endotipi in Oncologia, Metabolismo e Immunologia "G. Salvatore" - Consiglio Nazionale delle Ricerche (IEOMI-CNR), Napoli, Italy.ORCID 0000-0002-2184-0442
Giuseppe MatareseTreg Cell Lab, Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli studi di Napoli Federico II, Napoli, Italy.ORCID 0000-0001-9429-0616
Rosaria BenedettiDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. de Crecchio 7, Naples, Italy.ORCID 0000-0001-5517-5519
Simona BonavitaDipartimento di Scienze Mediche e Chirurgiche Avanzate, Università della Campania Luigi Vanvitelli, Napoli, Italia.ORCID 0000-0002-8561-9720

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesFc gamma receptor 3A (

methodsIn this observational cohort study, we enrolled people with MS treated with OCR consecutively between May 2022 and August 2025.

resultsIn 101 participants, 500 interinfusion intervals were analyzed. The odds of B-cell repopulation decreased with higher cycle number (odds ratio [OR] per cycle 0.77; 95% CI 0.65-0.91; DISCUSSION: Longer OCR infusion intervals were associated with higher odds of B-cell repopulation. The

Indexed as

Antibodies, Monoclonal, HumanizedB-LymphocytesImmunologic FactorsMultiple SclerosisReceptors, IgGAdultCohort StudiesFemaleHumansKiller Cells, NaturalMaleMiddle AgedAntibodies, Monoclonal, HumanizedFCGR3A protein, humanImmunologic FactorsocrelizumabReceptors, IgG

Identifiers

PMID42579840
PMCPMC13476018

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.