Evidence map›Paper›PMID 42579799›Full record

Observational studyJCI insight2026

Acute tubular injury versus acute interstitial nephritis in the kidney precision medicine project.

Jennifer A Schaub, Rajasree Menon, Ricardo Melo Ferreira, Elizabeth Kiernan, Insa M Schmidt, Christine P Limonte, Soumya Yennapureddy, Ying-Hua Cheng, Leal Herlitz, Avi Z Rosenberg and 35 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in JCI insight, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04334707 (Kidney Precision Medicine Project), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04334707 recruitingnot on this map

Kidney Precision Medicine Project

TypeobservationalSponsorIcahn School of Medicine at Mount SinaiRan2019 to 2027Enrolled1,000ConditionsAcute Kidney Failure, Acute Kidney Insufficiency, Acute Renal Failure, Acute Renal InjuryArmsKidney Biopsy, MRI, Retina Scan
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors.

Jennifer A SchaubDepartment of Internal Medicine, Division of Nephrology, and.
Rajasree MenonDepartment of Computational Medicine and Bioinformatics, Division of Nephrology, University of Michigan, Ann Arbor, Michigan, USA.
Ricardo Melo FerreiraDivision of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Elizabeth KiernanDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Insa M SchmidtDepartment of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, Massachusetts, USA.
Christine P LimonteDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Soumya YennapureddyDivision of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Ying-Hua ChengDivision of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Leal HerlitzDepartment of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio, USA.
Avi Z RosenbergDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Joel M HendersonDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
Kelly D SmithDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
Jeffrey B HodginDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Edgar OttoDepartment of Internal Medicine, Division of Nephrology, and.
Gilbert W MoeckelDepartment of Pathology, Yale University, New Haven, Connecticut, USA.
Lloyd G CantleySection of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Suman SettyDepartment of Pathology, University of Illinois at Chicago, Chicago, Illinois, USA.
Ulysses Gj BalisDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Dawit DemekeDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Agnes B FogoDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Andrew S BombackDivision of Nephrology, Department of Internal Medicine, and.
Vivette D D'AgatiDepartment of Pathology, Columbia University Irving Medical Center, New York, New York, USA.
Isaac E StillmanDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jose R TorrealbaDepartment of Pathology, Baylor College of Medicine, Houston, Texas, USA.
Allen R HendricksDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Erika BracamonteDepartment of Pathology and Laboratory Medicine, University of Arizona, Tucson, Arizona, USA.
Vanessa MorenoDepartment of Pathology and.
Pavan BhatrajuDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Amy K MottlDivision of Nephrology, University of North Carolina, Chapel Hill, North Carolina, USA.
Frank C BrosiusDepartment of Medicine, University of Arizona, Tucson, Arizona, USA.
Bijin ThajudeenDepartment of Medicine, University of Arizona, Tucson, Arizona, USA.
Steven G CocaDivision of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Paul M PalevskyRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Parmjeet S RandhawaDepartment of Pathology, Thomas E. Starzl Transplant Institute, and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Raghavan MuruganDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Laura BarisoniDepartment of Pathology, Division of AI and Computational Pathology, Department of Medicine, Division of Nephrology, Duke University, Durham, North Carolina, USA.
Charles E AlpersDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
Steven MenezDivision of Nephrology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
F Perry WilsonClinical and Translational Research Accelerator, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Dennis G MoledinaSection of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Michael T EadonDivision of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Matthias KretzlerDepartment of Internal Medicine, Division of Nephrology, and.
Jonathan HimmelfarbDivision of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Chirag R ParikhDivision of Nephrology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Kidney Precision Medicine Project

Funding

Central Hub for Kidney Precision MedicineU24DK114886 · NIDDK · UNIVERSITY OF WASHINGTON · PI Jonathan Himmelfarb, Matthias Kretzler · 2022 to 2026
$21.1M
KPMP Kidney Mapping and Atlas Project (KMAP)U01DK133090 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jonathan Himmelfarb, Matthias Kretzler · 2022 to 2026
$10.4M
Integrated spatial interrogation of cellular and molecular signatures of human kidney diseaseU01DK114923 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Tarek Maurice Ashkar, Pierre C Dagher · 2022 to 2026
$5.4M
Single cell multiomic and spatial atlas of acute and chronic kidney injuryU01DK114933 · NIDDK · WASHINGTON UNIVERSITY · PI Sanjay Jain · 2022 to 2026
$5.0M
Spatial Multi-Omics to Profile Metabolic Pathways for Kidney DiseaseU01DK114920 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Christopher R Anderton, Kumar Sharma · 2022 to 2026
$3.9M
Boston Chronic Kidney Disease Research Biopsy CenterU01DK133092 · NIDDK · BOSTON MEDICAL CENTER · PI Sylvia E Rosas, Sushrut S. Waikar · 2022 to 2026
$3.5M
Multimodal Imaging Mass Spectrometry and Spatial Omics for the Human KidneyU01DK133766 · NIDDK · VANDERBILT UNIVERSITY · PI Jeffrey M Spraggins · 2022 to 2026
$3.4M
PREcision Medicine through IntErrogation of Rna in the kidnEy (PREMIERE)U01DK114907 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Nir Hacohen, Jeffrey Benton Hodgin · 2022 to 2026
$3.2M
University of Illinois at Chicago KPMP CKD Recruitment SiteU01DK133081 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI JAMES P. LASH, Ana Catherine Ricardo · 2022 to 2026
$2.7M
AKI Matched Phenotype Linked Evaluation with Tissue (AMPLE-Tissue)U01DK114866 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Chirag R Parikh · 2022 to 2026
$2.6M
Cleveland Precision Medicine Chronic Kidney Disease CohortU01DK114908 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI JOHN F. O'TOOLE, EMILIO DANIEL POGGIO · 2022 to 2026
$2.2M
Geographic and Environmental Representation in Kidney Precision MedicineU01DK133095 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Frank C Brosius, Amy Mottl · 2022 to 2026
$2.1M
NIDDK NIH HHS U01 DK114866NIDDK NIH HHS U01 DK114907NIDDK NIH HHS U01 DK114908NIDDK NIH HHS U01 DK114920NIDDK NIH HHS U01 DK114923NIDDK NIH HHS U01 DK114933NIDDK NIH HHS U01 DK133081NIDDK NIH HHS U01 DK133090NIDDK NIH HHS U01 DK133091NIDDK NIH HHS U01 DK133092NIDDK NIH HHS U01 DK133093NIDDK NIH HHS U01 DK133095NIDDK NIH HHS U01 DK133097NIDDK NIH HHS U01 DK133113NIDDK NIH HHS U01 DK133766NIDDK NIH HHS U01 DK133768NIDDK NIH HHS U24 DK114886NIDDK NIH HHS UG3 DK114861NIDDK NIH HHS UH3 DK114861NIDDK NIH HHS UH3 DK114915NIDDK NIH HHS UH3 DK114926NIDDK NIH HHS UH3 DK114937
6 · The paper itself

Abstract

BACKGROUNDAcute interstitial nephritis (AIN) is a common cause of acute kidney injury (AKI), but the diagnosis may be missed as kidney biopsies are rarely obtained when acute tubular injury (ATI) is suspected.METHODSThe Kidney Precision Medicine Project is a cohort study that obtains kidney biopsies from individuals with AKI, which undergo pathologic and molecular interrogation. We compared ATI and AIN cases among the first 60 AKI participants.RESULTSOn clinicopathologic adjudication, 30 patients (50%) had a primary adjudicated diagnosis of ATI, 13 (22%) patients had AIN, 9 (15%) had diabetic nephropathy, and 3 (5%) had other conditions. There were increased interstitial white blood cells and tubulitis (P < 0.05 for both) in AIN compared with ATI. Prior to biopsy, the treating clinician suspected ATI in 83% of the cases with adjudicated ATI, while the treating clinician suspected AIN in 54% of the cases with AIN. Tissue transcriptomic signatures showed enrichment of proinflammatory signaling and increased expression of CXCL9, a chemokine induced by IFN-γ, in myeloid cells of participants with AIN. CXCL9 localized to inflammatory infiltration in spatial transcriptomic data.CONCLUSIONAdjudication of kidney biopsies revealed distinct pathologic and molecular profiles between ATI and AIN. Kidney biopsy should be considered more frequently in AKI, as AIN is clinically underrecognized.TRIAL REGISTRATIONClinicalTrials.gov NCT04334707.FUNDINGNational Institute of Diabetes and Digestive and Kidney Diseases grants U01DK133081, U01DK133091, U01DK133092, U01DK133093, U01DK133095, U01DK133097, U01DK114866, U01DK114908, U01DK133090, U01DK133113, U01DK133766, U01DK133768, U01DK114907, U01DK114920, U01DK114923, U01DK114933, U24DK114886, UH3DK114926, UH3DK114861, UH3DK114915, and UH3DK114937.

Indexed as

Acute Kidney InjuryKidney TubulesNephritis, InterstitialPrecision MedicineAdultAgedBiopsyChemokine CXCL9Cohort StudiesFemaleHumansKidneyMaleMiddle AgedChemokine CXCL9CXCL9 protein, humanChronic kidney diseaseImmunologyNephrology

Identifiers

PMID42579799
PMCPMC13464007

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Registered trials

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