Evidence map›Paper›PMID 42579397›Full record

ArticleCell biochemistry and function2026

Mitochondrial Mediated Apoptosis Evaluation of Myristicin on Triple Negative Breast Cancer Model Via Bcl2/Bid Pathway.

Sudhina Sufina Nazar, Aswathy Vadakkumkattle Ajaykumar, Janeesh Plakkal Ayyappan

Abstract read
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In one paragraph

Article in Cell biochemistry and function, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sudhina Sufina NazarTranslational Nanomedicine and Lifestyle Disease Research Laboratory, Department of Biochemistry, University of Kerala, Kariavattom campus, Thiruvananthapuram, Kerala, India.
Aswathy Vadakkumkattle AjaykumarDepartment of Anatomy, P K Das Institute of Medical Sciences, Vaniyamkulam, Ottapalam, Palakkad, Kerala, India.
Janeesh Plakkal AyyappanTranslational Nanomedicine and Lifestyle Disease Research Laboratory, Department of Biochemistry, University of Kerala, Kariavattom campus, Thiruvananthapuram, Kerala, India.ORCID https://orcid.org/0000-0001-8074-3709

Funding

Indian Council of Medical Research 10.13039/501100001411Indian Council of Medical Research 2021-8110Kerala Biotechnology Commission 10.13039/501100020626Kerala Biotechnology Commission KSCSTE/1025/2023-YIPBKBCStart-up grant for new faculty from University Grants Commission (UGC) India F.30-596/2021Start-up Research Grant from Science and Engineering Research Board (SERB) India SRG/2021/001831University of Kerala research support in the form of Plan and Nonplan funds 7615/2021/UOK
6 · The paper itself

Abstract

Among 15-20 cases of breast cancer, triple-negative breast cancer (TNBC) is the deadliest form of the disease. The most effective form of treatment for this type of cancer is still targeted chemotherapy because it lacks hormone receptors. Myristicin, an active aromatic compound with anticancer properties, is mostly found in nutmeg. Antitumor, antioxidant, and antimicrobial activity are among few of the numerous properties of myristicin. On TNBC cells, the exact modes of action are mostly unidentified. This study shows that myristicin triggered the mitochondria-mediated apoptosis in MDA-MB-231 cells. The MTT assay assessed the anti-proliferative potential of myristicin on TNBC cells (IC

Indexed as

Antineoplastic AgentsApoptosisBenzyl CompoundsDioxolanesMitochondriaProto-Oncogene Proteins c-bcl-2PyrogallolTriple Negative Breast NeoplasmsAllylbenzene DerivativesAnimalsCell Line, TumorCell ProliferationFemaleHumansMDA-MB-231 CellsMiceAllylbenzene DerivativesAntineoplastic AgentsBCL2 protein, humanBenzyl CompoundsDioxolanesmyristicinProto-Oncogene Proteins c-bcl-2Pyrogallolapoptosismitochondrial stressmyristicinROSTNBC

Identifiers

PMID42579397
PMCPMC13460386

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.