Evidence map›Paper›PMID 42579349›Full record

ArticleThe Journal of clinical investigation2026

Neuropeptide Y deficiency perturbs L-type calcium and outward potassium currents leading to ventricular arrhythmogenesis in mice.

Seyi E Elasoru, Christian Miccile, Jingwu Pan, Zhaoyang Zhang, Kalyanam Shivkumar, Herbert Herzog, Robert D Harvey, Zhilin Qu, Olujimi A Ajijola

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Seyi E ElasoruDepartment of Medicine-Cardiology, UCLA, Los Angeles, California, USA.
Christian MiccileDepartment of Medicine-Cardiology, UCLA, Los Angeles, California, USA.
Jingwu PanDepartment of Medicine-Cardiology, UCLA, Los Angeles, California, USA.
Zhaoyang ZhangDepartment of Physics, School of Physical Science and Technology, Ningbo University, Ningbo, Zhejiang, China.
Kalyanam ShivkumarDepartment of Medicine-Cardiology, UCLA, Los Angeles, California, USA.
Herbert HerzogSt. Vincent's Centre for Applied Medical Research, Darlinghurst, New South Wales, Australia.
Robert D HarveyDepartment of Pharmacology, University of Nevada, Reno, Nevada, USA.
Zhilin QuDepartment of Medicine-Cardiology, UCLA, Los Angeles, California, USA.
Olujimi A AjijolaDepartment of Medicine-Cardiology, UCLA, Los Angeles, California, USA.

Funding

Neural Control of Myocardial Excitability at the Nerve Myocyte InterfaceP01HL164311 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KALYANAM SHIVKUMAR · 2023 to 2026
$11.3M
Understanding Modulation of Neuronal Subpopulations by Sympathetic GliaR01HL162717 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A · 2022 to 2025
$2.4M
A population-based computational approach for arrhythmia prediction and therapyR01HL175074 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHILIN QU · 2024 to 2026
$1.2M
NHLBI NIH HHS P01 HL164311NHLBI NIH HHS R01 HL162717NHLBI NIH HHS R01 HL175074
6 · The paper itself

Abstract

Elasoru and colleagues present findings revealing a novel role for Neuropeptide Y (a sympathetic co-transmitter) in cardiomyocyte ion channel regulation and action potential duration.

Indexed as

Action PotentialsArrhythmias, CardiacCalcium Channels, L-TypeHeart VentriclesMyocytes, CardiacNeuropeptide YAnimalsMiceCalcium Channels, L-TypeNeuropeptide YArrhythmiasCardiologyMouse modelsNeuroscience

Identifiers

PMID42579349
PMCPMC13626841

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.