Evidence map›Paper›PMID 42579264›Full record

ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2026

Observation of glutathione intra- and extracellular membrane with large Stokes shift probe modified by long alkyl chains.

Lin Li, Shao-Bin Sun, Dan Qiao, Jing Zhou, Lin-Qing Wang, Jian-Yong Wang

Abstract read
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In one paragraph

Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lin LiSchool of Life Sciences, Henan Province Engineering Technology Research Center of Antibody Screening and Diagnostic, Zhengzhou Normal University, Zhengzhou, No. 16, Yingcai Street, Huiji District, Zhengzhou, 450004, Henan, P. R. China. lilin29pumc@163.com.ORCID http://orcid.org/0000-0002-5261-0789
Shao-Bin SunFaculty of Light Industry, State Key Laboratory of Green Papermaking and Resource Recycling, Key Laboratory of Paper Science and Technology of Ministry of Education, Qi Lu University of Technology (Shandong Academy of Sciences), Jinan, 250353, P. R. China.
Dan QiaoSchool of Life Sciences, Henan Province Engineering Technology Research Center of Antibody Screening and Diagnostic, Zhengzhou Normal University, Zhengzhou, No. 16, Yingcai Street, Huiji District, Zhengzhou, 450004, Henan, P. R. China.
Jing ZhouFaculty of Light Industry, State Key Laboratory of Green Papermaking and Resource Recycling, Key Laboratory of Paper Science and Technology of Ministry of Education, Qi Lu University of Technology (Shandong Academy of Sciences), Jinan, 250353, P. R. China.
Lin-Qing WangSchool of Life Sciences, Henan Province Engineering Technology Research Center of Antibody Screening and Diagnostic, Zhengzhou Normal University, Zhengzhou, No. 16, Yingcai Street, Huiji District, Zhengzhou, 450004, Henan, P. R. China.
Jian-Yong WangFaculty of Light Industry, State Key Laboratory of Green Papermaking and Resource Recycling, Key Laboratory of Paper Science and Technology of Ministry of Education, Qi Lu University of Technology (Shandong Academy of Sciences), Jinan, 250353, P. R. China. wjy@qlu.edu.cn.ORCID http://orcid.org/0000-0002-5254-1525

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A naphthylimide dye-based fluorescent probe (Nap-Mem-GSH) was synthesized for the detection of Glutathione inside and outside cell membranes. This probe carried a 2-Hydroxyquinoline fragment as a recognition site on top of a naphthalimide dye, which exhibits better selective and fluorimetric response toward Glutathione in natural media. The long alkyl chain confers a cell membrane targeting role to Nap-Mem-GSH. Therefore, the detection of intra-and extracellular glutathione inside and outside the cell membrane can be realized by Nap-Mem-GSH. Meanwhile, Nap-Mem-GSH not only has a large Stokes shift (160 nm), a low detection limit and a rapid response toward GSH, but also has the advantages of low cytotoxicity and good membrane permeability to living cells, and has been successfully applied to effectively detect and image intracellular glutathione by confocal fluorescence imaging.

Indexed as

Cell MembraneFluorescent DyesGlutathioneNaphthalimidesAnimalsFluorescent Chemosensor CompoundsHumansMicroscopy, ConfocalOptical ImagingZebrafishFluorescent Chemosensor CompoundsFluorescent DyesGlutathioneNaphthalimidesCell imagingCell membrane targetingGlutathioneLarge Stokes shiftZebrafish imaging

Identifiers

PMID42579264

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.