Evidence map›Paper›PMID 42579074›Full record

ArticleJournal of cancer survivorship : research and practice2026

Transition outcomes in a diverse cohort of higher-risk young adult survivors of childhood cancer in an established care model.

Amie E Hwang, Nikhil Kumar, Maureen Cairns, Yi Juin Tan, Saptati Priya Bhattacharjee, Ellen K Chang, Hsuan-Hsiu Annie Chen, Sarayu Kumar, Shuyao Ran, Kimberly A Miller and 1 more

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Article in Journal of cancer survivorship : research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Amie E HwangDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Nikhil KumarCancer and Blood Disease Institute, Children's Hospital Los Angeles, 4650 Sunset Blvd, Los Angeles, CA, 90027, USA. nikhilkumar1@gmail.com.
Maureen CairnsDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Yi Juin TanCancer and Blood Disease Institute, Children's Hospital Los Angeles, 4650 Sunset Blvd, Los Angeles, CA, 90027, USA.
Saptati Priya BhattacharjeeCancer and Blood Disease Institute, Children's Hospital Los Angeles, 4650 Sunset Blvd, Los Angeles, CA, 90027, USA.
Ellen K ChangDivision of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Hsuan-Hsiu Annie ChenGreat Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Sarayu KumarDepartment of Pediatrics, Rady Children's Health Orange County, Orange, CA, USA.
Shuyao RanColumbia University, New York, NY, USA.
Kimberly A MillerDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
David R FreyerDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
NCI NIH HHS P30 CA014089
6 · The paper itself

Abstract

purposeYoung adult survivors of childhood cancer frequently experience transition failure when transferred to adult-focused survivorship care, yet associated factors within specific care models remain poorly studied.

methodsThis retrospective cohort study included higher-risk young adult survivors transitioned from Children's Hospital Los Angeles to an affiliated adult-focused survivorship clinic from 2010 to 2018 using a protocolized pathway. Transition failure was defined as no documented adult-clinic visit within 2 years of transition launch. Late effects were defined per the Common Terminology Criteria for Adverse Events (CTCAE, v5.0).

resultsThe sample (N = 289) had mean age 22.9 years (range 17-53), was 54.0% male, and 52.2% Hispanic. Transition failure occurred in 143 (49.5%). In multivariable analyses, significantly lower odds of failure (OR, 95% CI) were observed for multiple prior pediatric survivorship visits (2 vs. 1: 0.28, 0.15-0.55; ≥ 3 vs. 1: 0.42, 0.20-0.87), higher education (college vs. high school: 0.50, 0.26-0.95), and high-dose anthracyclines (vs. none/low: 0.29, 0.11-0.77), with borderline higher odds for CTCAE-defined psychiatric disorders (2.04, 0.99-4.21). In exploratory ethnicity-stratified analysis, psychiatric disorders were associated with higher odds of failure only among Hispanic survivors (4.06, 1.37-12.01), with lower odds for age ≥ 22 years at transition (0.39, 0.16-0.95).

conclusionsAt 2 years, half of survivors experienced transition failure, which was associated with fewer prior survivorship visits and lower educational attainment; psychiatric comorbidity showed a borderline association. IMPLICATIONS FOR CANCER SURVIVORS: Even within a highly structured model, early survivorship transition failure is common, and identifiable patient subsets need additional support. More research concerning post-transition barriers is needed.

Indexed as

Cancer survivorshipChildhood cancer survivorsHealth equityLoss to follow-upPsychiatric comorbidityTransition to adult care

Identifiers

PMID42579074

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.