ArticleCell biochemistry and biophysics2026
Predicting of Nano Cerium/Hydroxyapatite Efficiency Against γ- Irradiation Induced Heart Failure in Albino Rats.
Article in Cell biochemistry and biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The study was conducted to investigate the therapeutic potential of nano cerium hydroxyapatite (nCe/HAp) on γ-irradiation (IR) induced cardiac failure in male rats. Cardiac failure was induced by exposure to 9 Gy of γ-radiation. The nanocomposite nCe/HAp was administered at a dose of 50 mg/kg b.w. intravenously. The levels of oxidative status, heart enzymes, troponin I (cTnI), total creatine kinase (CK), creatine phosphokinase isoenzyme (CK-MB), and lactate dehydrogenase (LDH) were measured, in addition to immune status, by measuring the levels of nuclear factor kappa B (NF-kB), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP). Pathological analysis of heart tissue was undertaken for all animals. The results revealed the effectiveness of nCe/HAp in ameliorating most of the examined parameters by significantly elevating the GSH and SOD activity levels. On the other side, there was a significant decline in the serum NO, MDA, cTnI, NF-kB, CK, CK-MB and LDH levels upon treatment. Microscopic evaluation of tissue samples confirmed the biochemical outcomes and the variance between the control and the other treated groups. In conclusion, nCe/HAp succeeded in preventing heart damage to a considerable degree, and paves the way for Ce/HAp nanocomposites as promising effective candidates for mitigating radiation treatments.
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