ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2026
Personal Talc Use and Incident Lung Cancer.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTalc is a known risk factor for some lung diseases due to its small particle size, commonly aerosolized form, and possible contamination with asbestos, a known lung carcinogen. Personal talc-based body powder (talc) use is common among U.S. women, but the association of talc use and lung cancer has not been studied in non-occupational settings.
methodsAt enrollment (2003-2009), Sister Study participants reported talc use in the last year and ages 10-13. We used Cox proportional hazards models to estimate covariate-adjusted hazards ratios (HRs) and 95% confidence intervals (CIs) for the associations between talc use and incident lung cancer.
resultsAmong 49,592 eligible women, 41% reported using talc in the last year and 641 reported a new lung cancer diagnosis. Self-reported talc use was not consistently associated with incident lung cancer: HR=0.91 (95% CI: 0.78-1.07) for talc use in the last year; HR=0.94 (0.80, 1.10) for talc use ages 10-13.
conclusionsNo consistent associations were observed between talc use and lung cancer overall, though some suggestive positive associations observed among never-smokers and for lung adenocarcinomas may warrant further investigation. IMPACT: Population-based research on personal care product use is critical to improving our understanding of the impacts of potentially harmful substances, and their known or unknown contaminants, on human health.
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