Evidence map›Paper›PMID 42578730›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Chemoenzymatic Radiosynthesis of a Gluconate Transporter-Targeted In Vivo Bacterial Sensor From Clinical [

Sang Hee Lee, Jung Min Kim, Joseph Blecha, Robert R Flavell, Michael A Ohliger, Joanne Engel, Youngho Seo, David M Wilson

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sang Hee LeeDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0001-8578-9968
Jung Min KimDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.ORCID https://orcid.org/0009-0003-9492-510X
Joseph BlechaDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Robert R FlavellDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-8694-1199
Michael A OhligerDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0001-6878-8189
Joanne EngelDepartment of Medicine, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-2168-9711
Youngho SeoDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0001-5908-6636
David M WilsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-1095-046X

Funding

New radiotracer development to study immune cell mobilization of granzyme proteolytic activityR01AI161027 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIK, CHARLES SCOTT, EVANS, MICHAEL JOHN · 2021 to 2024
$2.8M
Sensing living P. aeruginosa using D-alanine derived radiotracersR01EB030897 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ENGEL, JOANNE N., OHLIGER, MICHAEL · 2021 to 2024
$2.7M
Chemoenzymatic radiosyntheses of [18F]FDG-derived oligosaccharides for S. aureus detectionR01AI181378 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Michael Ohliger, David M Wilson · 2024 to 2026
$2.3M
Novel imaging agents of oxidative stress in the pathophysiology of the central nervous systemR01EB028338 · NIBIB · UNIVERSITY OF VIRGINIA · PI NEUMANN, KIEL · 2020 to 2020
$2.1M
[18F]fluoromannitol: A novel imaging agent to delineate osteomyelitis in sickle cell diseaseR01AI192221 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Amanda Marie Green, Kiel Neumann · 2025 to 2026
$1.8M
High-throughput microPET/CT at UCSF Preclinical Imaging CoreS10OD034286 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEO, YOUNGHO · 2023 to 2023
$662k
Imaging bacterial infection using deuterium-enriched sugar alcohols.R21AI164684 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WILSON, DAVID M · 2021 to 2022
$444k
National Institute of Health R01AI192221NIAID NIH HHS R01 AI161027NIAID NIH HHS R01AI161027NIAID NIH HHS R01 AI181378NIAID NIH HHS R01AI181378NIAID NIH HHS R01 AI192221NIAID NIH HHS R21 AI164684NIAID NIH HHS R21AI164684NIBIB NIH HHS R01 EB028338NIBIB NIH HHS R01EB028338NIBIB NIH HHS R01 EB030897NIBIB NIH HHS R01EB030897NIH HHS S10 OD034286NIH High-End Instrumentation S10OD034286
6 · The paper itself

Abstract

Many bacteria, but not mammalian cells, can directly import and metabolize extracellular gluconate via gluconate permease (GntP) and kinase (GntK). We hypothesized that fluorine-18 labeled gluconic acid ([

Indexed as

Fluorodeoxyglucose F18GluconatesRadiopharmaceuticalsStaphylococcus aureusAnimalsKlebsiella pneumoniaeMicePositron-Emission TomographyFluorodeoxyglucose F18Gluconatesgluconic acidRadiopharmaceuticals[18F]FDGchemoenzymatic radiosynthesisgluconate metabolismglucose oxidasepositron emission tomography

Identifiers

PMID42578730
PMCPMC13638095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.