Evidence map›Paper›PMID 42578679›Full record

ArticleAngewandte Chemie (International ed. in English)2026

A Synthetic β-Mannan Epitope Enables Immunization and Detection of Candida auris.

Emelie E Reuber, Arnab Pradhan, Ian Leaves, Rajat K Singh, Emer Hickey, Carola Geiler, Neil A R Gow, Alistair J P Brown, Peter H Seeberger

Abstract read
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In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emelie E ReuberDepartment of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.ORCID https://orcid.org/0009-0007-0624-542X
Arnab PradhanMRC Centre for Medical Mycology, University of Exeter, Exeter, UK.
Ian LeavesMRC Centre for Medical Mycology, University of Exeter, Exeter, UK.
Rajat K SinghDepartment of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Emer HickeyMRC Centre for Medical Mycology, University of Exeter, Exeter, UK.
Carola GeilerDepartment of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany.
Neil A R GowMRC Centre for Medical Mycology, University of Exeter, Exeter, UK.ORCID https://orcid.org/0000-0002-2776-5850
Alistair J P BrownMRC Centre for Medical Mycology, University of Exeter, Exeter, UK.
Peter H SeebergerDepartment of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.

Funding

Exeter Biomedical Research Centre University of ExeterMax-Planck SocietyUK Medical Research Council MR/M026663/2UK Medical Research Council MR/N006364/2UK Medical Research Council MR/Y002164/1UK National Institute for Health and Care ResearchWellcome TrustWellcome Trust Investigator award 224323
6 · The paper itself

Abstract

Candida auris is an emerging multidrug-resistant fungal pathogen for which neither vaccines nor rapid diagnostics are available. Defined fungal glycan epitopes offer a chemically precise route toward both immunization and detection. Here, we show that a synthetic β-mannan tetrasaccharide, β-(1,2)Man-α-(1,2)Man-α-(1,2)Man-α-(1,2)Man, functions as a lead epitope against C. auris. Conjugation of this glycan to the carrier protein CRM

Indexed as

Candida aurisCandidiasisEpitopesImmunizationMannansAnimalsImmunoglobulin GMiceEpitopesImmunoglobulin GMannansantibodiesCandidacarbohydratesglycoconjugatesvaccines

Identifiers

PMID42578679
PMCPMC13638085

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.