Evidence map›Paper›PMID 42578673›Full record

ArticleMicrobiology spectrum2026

Resistome and microbiome-immune interactions in an Eastern European population with high antibiotic use.

Bogdan Mirăuță, Anca-Lelia Riza, Ioana Streata, Andrei Pirvu, Stefania Dorobantu, Adina Dragos, Marius Surleac, Mihai G Netea

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bogdan MirăuțăHuman Genomics Laboratory, Functional Genomics Group, University of Medicine and Pharmacy of Craiova, Craiova, Romania.ORCID 0000-0002-9733-292X
Anca-Lelia RizaHuman Genomics Laboratory, Functional Genomics Group, University of Medicine and Pharmacy of Craiova, Craiova, Romania.ORCID 0000-0003-2073-8865
Ioana StreataHuman Genomics Laboratory, Functional Genomics Group, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Andrei PirvuHuman Genomics Laboratory, Functional Genomics Group, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Stefania DorobantuHuman Genomics Laboratory, Functional Genomics Group, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Adina DragosHuman Genomics Laboratory, Functional Genomics Group, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Marius SurleacThe Research Institute of the University of Bucharest, Bucharest, Romania.
Mihai G NeteaHuman Genomics Laboratory, Functional Genomics Group, University of Medicine and Pharmacy of Craiova, Craiova, Romania.

Funding

Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI) PN-IV-P6-6.1-CoEx-2024-0196 (17CoEx/2026)Ministry of European Funds, Romania - Competitiveness Operational Programme P_37_745, MySMIS 103454, Contract No. 31/01.09.2016Ministry of Research, Innovation and Digitalization, Romania - National Recovery and Resilience Plan (PNRR), Pillar III, Component 9, Investment I8 PNRR/2022/C9/MCID/I8, Contract No. 760057/23.05.2023
6 · The paper itself

Abstract

The gut microbiome influences host health, affecting gastrointestinal, metabolic, immune, cardiovascular, and neurological functions. A balanced microbiome is associated with favorable health outcomes. However, excessive antibiotic use and dietary habits can disrupt this ecosystem, leading to dysbiosis and affecting body homeostasis. This first comprehensive metagenomic analysis of the gut microbiome in a healthy Romanian cohort, a population underrepresented in microbiome studies and characterized by high antibiotic consumption, addresses a gap in current microbiome research. We report an enrichment of Enterobacteriaceae although overall composition is more comparable to other European than non-European cohorts. Community configurations align with established enterotype patterns, and our analysis provides insight into their relationship with within-phylum diversity. The analysis of antimicrobial resistance provides insight into the prevalence of resistance genes within this reservoir. We specifically report the presence of

Indexed as

Anti-Bacterial AgentsBacteriaDrug Resistance, BacterialGastrointestinal MicrobiomeFecesHumansMetagenomicsRomaniaAnti-Bacterial Agentsantimicrobial resistanceenterobacteriaceaegut microbiomeimmunity

Identifiers

PMID42578673
PMCPMC13532179

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.