ReviewJournal of pain research2026
The Analgesic Effects and Anti-Inflammatory Mechanisms of Acupuncture at Zusanli (ST36) in Animal Models of Rheumatoid Arthritis: Systematic Review and Meta-Analysis.
Review in Journal of pain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aimed to systematically evaluate the analgesic and anti-inflammatory effects of isolated acupuncture at Zusanli (ST36) in animal models of rheumatoid arthritis (RA), providing evidence-based insights for clinical translation and mechanism research. Methods: PubMed, Web of Science, and Embase were searched from inception to December 2025 for controlled trials of standalone ST36 acupuncture in RA animals. Two reviewers independently screened studies, extracted data, assessed risk of bias, and meta-analyses were performed via RevMan 5.4 and Stata 18.0. Results: Twenty-four studies were included. ST36 acupuncture significantly elevated paw withdrawal latency(PWL), tail flick latency(TFL), ear thermal pain threshold, paw withdrawal threshold (PWT) and knee joint pressure pain threshold (all Conclusion: Isolated acupuncture at ST36 exerts significant analgesic and anti-inflammatory effects in RA animal models, potentially mediated by regulating inflammatory cytokines and immune cells. However, methodological quality limitations and publication bias restrict the findings, requiring validation by high-quality future studies.
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