ArticleJournal of inflammation research2026
Characterization of Peripheral Blood Immune Cell Features in SSA/SSB Double‑Positive Primary Sjögren's Disease Based on Single‑Cell RNA Sequencing.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Objective: Primary Sjögren's disease (pSjD) is a chronic systemic autoimmune disease characterized by lymphocyte infiltration of the exocrine glands. Anti-SSA (Ro) and anti-SSB (La) antibodies are diagnostic serological markers of pSjD. However, whether the coexistence of anti-SSA and anti-SSB antibodies defines an immunologically distinct subtype at the single-cell level remains unclear. Methods: From our established single-cell peripheral blood mononuclear cells (PBMCs) RNA sequencing database for pSjD, 3 healthy controls, 5 SSA Results: Seven major immune cell populations were identified, including T cells, B cells, monocytes/macrophages, NK cells, plasmacytoid dendritic cells (pDCs), mast cells, and platelet-megakaryocytes. Further subpopulation analysis revealed a more pronounced immune transcriptional reprogramming in the SSA Conclusion: SSA
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