ArticleInfection and drug resistance2026
Exploratory Evaluation of Chlorhexidine Decolonization and Skin Colonization Dynamics of
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
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Abstract
Objective: Methods: Four consecutive Results: Skin colonization burden declined progressively in both intervention patients: Case A fell from 34 colony-forming units (CFU)/swab at baseline to 4 CFU/swab by Day 12, and Case B from 10 CFU/swab (Day 4) to 5 CFU/swab by Day 6 (discharged on Day 10). Colonization burden did not decline in the non-intervention group (Case C: 24-30 CFU/swab in groin across Day 0-12). Clinical outcomes differed between groups, but the non-randomized design, baseline imbalance in infection status, and universal co-infection with multidrug-resistant organisms preclude any causal inference. Conclusion: In this four-patient pilot study, twice-daily chlorhexidine decolonization was accompanied by a reduction in skin colonization burden, but the findings are hypothesis-generating only. The small sample size, non-randomized design, baseline differences, and lack of molecular typing limit interpretation. Adequately powered, preferably randomized, studies with whole-genome sequencing are needed.
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