ArticleThe Lancet. Primary care2025
Preventing, identifying, and managing sepsis in the community: research and clinical priorities.
Abstract read
In one paragraph
Article in The Lancet. Primary care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Epidemiology, multimorbidity patterns and outcomes of paediatric sepsis admissions in Ireland 2020-2025.European journal of pediatrics · 2026Observational
- Clinically recognized sepsis in older adults admitted to medical wards: patient characteristics and hospital outcomes from the REPOSI register.Internal and emergency medicine · 2026Article
- Diagnosing Sepsis in Primary Care: Navigating Clinical Uncertainty Across Vulnerable Patient Groups.Cureus · 2026Review
- Sepsis policy, guidelines, and standards in Canada: a jurisdictional scoping review.BMC health services research · 2026Article
- Emergency Department Utilisation and Related Costs in People With and Without Dementia in Their Last Years of Life.Emergency medicine Australasia : EMA · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Kristina E RuddCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).
Adrienne G RandolphCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).
Derek C AngusCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).
Michael BauerCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).
Christopher F ChesleyCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).
Michael R FilbinCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).
Grace JenqCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).
Jordan A KempkerCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).
Adam C LevineCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).
Phillip LevyCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).
Flavia R MachadoCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).
Nicholas M MohrCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).
Robert QuinnCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).
Kathryn RowanCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).
Manu Shankar-HariCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).
Fatima SheikhCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).
Patrycja SlebodaCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).
Jeb S TeichmanCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).
Thierry CalandraCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).
Hallie C PrescottCenter for Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA (K E Rudd MD, Prof D C Angus MD); Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA (Prof A G Randolph MD); Department of Anaesthesia, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Pediatrics, Harvard Medical School, Boston, MA, USA (Prof A G Randolph); Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany (Prof M Bauer MD); Division of Pulmonary, Allergy and Critical Care, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley MD); Palliative and Advanced Illness Research Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA (C F Chesley); Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA (C F Chesley); Department of Emergency Medicine, Harvard Medical School, Boston, MA, USA (M R Filbin MD); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA (Prof G Jenq MD, H C Prescott MD); Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA (J A Kempker MD); Watson Institute for International and Public Affairs, Brown University, Providence, RI, USA (Prof A C Levine MD); Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA (Prof A C Levine); Department of Emergency Medicine, Wayne State University, Detroit, MI, USA (Prof P Levy MD); Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil (Prof F R Machado MD); Departments of Emergency Medicine, Anesthesia, and Epidemiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA (Prof N M Mohr MD); Sepsis Scout, San Francisco, CA, USA (R Quinn PhD); CytoVale, San Francisco, CA, USA (R Quinn); Intensive Care National Audit and Research Centre, London, UK (Prof K Rowan PhD); Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK (Prof K Rowan); Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK (Prof M Shankar-Hari PhD); Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada (F Sheikh MSc); Weissman School of Arts and Sciences, Baruch College, City University of New York, New York, NY, USA (P Sleboda PhD); Families Fighting Flu, Prospect, KY, USA (J S Teichman MD); Service of Immunology and Allergy, Center of Human Immunology Lausanne, Department of Medicine and Department of Laboratory Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland (Prof T Calandra MD); VA Center for Clinical Management Research, Ann Arbor, MI, USA (H C Prescott).
Funding
The Syndemic of Sepsis, Multimorbidity, Aging, and Low Healthcare Access and Quality in the United StatesK23GM141463 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RUDD, KRISTINA ELIZABETH · 2021 to 2025
$921kInvestigating mechanisms of disparities for critically ill patients with acute respiratory failure and sepsis.K01HL171466 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Christopher Francis Chesley · 2024 to 2026
$483kAHRQ HHS R01 HS026725NHLBI NIH HHS K01 HL171466NIGMS NIH HHS K23 GM141463Wellcome Trust
Abstract
Sepsis, defined as life-threatening acute organ dysfunction due to infection, is generally considered a hospital-based issue. However, sepsis usually begins in the community, where knowledge of sepsis is scarce, diagnosis is difficult, and resources vary. Community-based interventions might offer the best opportunity for prevention, prompt diagnosis, and improved outcomes. In this Viewpoint, we address current gaps and limitations in understanding of sepsis in the community and outline research priorities, clinical priorities, and existing initiatives across four domains: mitigation (ie, reduction of population-based sepsis risk), monitoring (ie, screening for sepsis in individuals at high risk of sepsis), measurement (ie, identification of sepsis in the community), and management (ie, treatment of sepsis in the community). We propose a pathway to improve the care of individuals with, or at risk of, sepsis in the community and delineate the next steps to advance the field.
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