Evidence map›Paper›PMID 42577866›Full record

ArticleCell press blue2026

Dysregulated NF-κB dynamics impair proteostasis and drive premature differentiation in aging B cell development.

Yu-Sheng Lin, Valentina Alonso, Apeksha Singh, Yi Liu, Ying Tang, Arnav Mehta, Jennifer K King, May Paing, Nathan Salomonis, H Leighton Grimes and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell press blue, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yu-Sheng LinSignaling Systems Laboratory, Department of Microbiology, Immunology, and Molecular Genetics (MIMG), University of California, Los Angeles, Los Angeles, CA, USA.
Valentina AlonsoSignaling Systems Laboratory, Department of Microbiology, Immunology, and Molecular Genetics (MIMG), University of California, Los Angeles, Los Angeles, CA, USA.
Apeksha SinghSignaling Systems Laboratory, Department of Microbiology, Immunology, and Molecular Genetics (MIMG), University of California, Los Angeles, Los Angeles, CA, USA.
Yi LiuSignaling Systems Laboratory, Department of Microbiology, Immunology, and Molecular Genetics (MIMG), University of California, Los Angeles, Los Angeles, CA, USA.
Ying TangSignaling Systems Laboratory, Department of Microbiology, Immunology, and Molecular Genetics (MIMG), University of California, Los Angeles, Los Angeles, CA, USA.
Arnav MehtaSignaling Systems Laboratory, Department of Microbiology, Immunology, and Molecular Genetics (MIMG), University of California, Los Angeles, Los Angeles, CA, USA.
Jennifer K KingDivision of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
May PaingDivision of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
Nathan SalomonisDepartment of Biomedical Informatics, University of Cincinnati, Cincinnati, OH, USA.
H Leighton GrimesDepartment of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH, USA.
Jennifer J ChiaSignaling Systems Laboratory, Department of Microbiology, Immunology, and Molecular Genetics (MIMG), University of California, Los Angeles, Los Angeles, CA, USA.
Dinesh S RaoDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Alexander HoffmannSignaling Systems Laboratory, Department of Microbiology, Immunology, and Molecular Genetics (MIMG), University of California, Los Angeles, Los Angeles, CA, USA.

Funding

Cell decision underlying B-cell immune responsesR01AI132731 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOFFMANN, ALEXANDER · 2018 to 2022
$2.2M
The IRF regulatory network in innate immune training of macrophagesR01AI185026 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alexander Hoffmann · 2025 to 2026
$1.3M
From B-cell decisions to antibody repertoiresR01AI193096 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alexander Hoffmann · 2026 to 2026
$744k
NIAID NIH HHS R01 AI132731NIAID NIH HHS R01 AI185026NIAID NIH HHS R01 AI193096
6 · The paper itself

Abstract

Aging and inflammation reduce bone marrow B cell output. While myeloid bias among multi-potent progenitors is one cause, how the developmental cascade of B-committed progenitors is affected remains less well characterized. Here, we identify dynamic modulation of the inflammation response factor NF-κB as a hallmark of healthy lymphopoiesis, but it is diminished in aged B-lymphopenic mice. Indeed, genetic dysregulation of NF-κB dynamics results in severe B-lymphopenia. Model-aided analysis of

Identifiers

PMID42577866
PMCPMC13455761

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.