Evidence map›Paper›PMID 42577862›Full record

ArticleJournal of Cancer2026

GPCRs interaction with LGR5: Implications to cancer stemness.

Jeetendra K Nag, Ganesh Subedi, Tatyana Rudina, Rachel Bar-Shavit

Abstract read
In one paragraph

Article in Journal of Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jeetendra K NagDepartment of Heart, Blood and Kidney Research, Cleveland, Clinic Research, Cleveland, OH 44195 USA.
Ganesh SubediDepartment of Heart, Blood and Kidney Research, Cleveland, Clinic Research, Cleveland, OH 44195 USA.
Tatyana RudinaSharett Institute of Oncology, Hadassah-Hebrew University, Medical Center, Jerusalem, Israel.
Rachel Bar-ShavitSharett Institute of Oncology, Hadassah-Hebrew University, Medical Center, Jerusalem, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methods: Western blots, Co-immunoprecipitation (co-IP) analysis, RT-PCR, Results: It is demonstrated that protease-activated receptor 4 (PAR Conclusions: As was previously shown for PAR

Indexed as

cancer stem cells (CSCs)G-protein coupled receptors (GPCRs)LGR5protease-activated receptors (PARs)β-catenin stabilization

Identifiers

PMID42577862
PMCPMC13455214

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.