ArticleFrontiers in medicine2026
Value of SPECT/CT in the diagnosis of juvenile idiopathic arthritis in young children: a retrospective case-control study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood, with early diagnosis remaining challenging due to its heterogeneous manifestations and complex pathogenesis. Nuclear medicine imaging, like single photon emission computed tomography (SPECT), which has proven valuable in quantifying inflammation and monitoring disease activity in adult rheumatoid arthritis (RA), may also have diagnostic potential in JIA, given the similarities in synovitis and joint damage between JIA and RA. Method: This retrospective case-control study included 29 JIA patients (aged 1-13 years) and 55 non-JIA controls (aged 1-16 years), all undergoing Results: JIA patients showed significantly higher median BS in all target joints, with the most significant differences in bilateral wrists (left wrist: median = 3.25, IQR = 1.35, Conclusions: SPECT-based wrist brightness scoring is a potential objective imaging tool for JIA diagnosis. No significant diagnostic value was found in the hip, knee, or ankle joints.
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