ArticleNature. Mental health2025
Alterations in aperiodic neural activity associated with major depressive disorder.
Article in Nature. Mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed.
- Frequency-decomposed EEG microstate analysis reveals altered cross-frequency coordination in adolescent major depressive disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Gamma and beta power and the 1/f slope vary across a spectrum of depression severity.Translational psychiatry · 2026Article
- Scale-Free Neurodynamics as Functional Fingerprint of Brain Regions.Bioengineering (Basel, Switzerland) · 2026Article
- Aperiodic Signatures of Stress Sensitivity and Depression Recurrence in Adolescents.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Age-Related Differences and Effects of Internalizing Symptoms on Aperiodic Neural Activity in Adolescents.Psychophysiology · 2026Article
- Emotional neglect in childhood modulates aperiodic offset in the left pars orbitalis in adulthood.Frontiers in neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
Historically, aperiodic neural activity (i.e., the 1/f exponent and offset of electroencephalogram (EEG) power spectra) has been treated as neural noise. However, recent work has highlighted associations among aperiodic activity, aging, cognition, and psychopathology. While depression has been associated with cognitive deficits and dysregulation of excitatory/inhibitory neural mechanisms linked to aperiodic activity, to date, few studies have compared aperiodic activity in adults with and without depression, and none have evaluated aperiodic activity as a function of depressive chronicity. Here, individuals with depression (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.