ArticleFatigue : biomedicine, health & behavior2026
Vertical saccadic slowing is associated with fatigue in multiple sclerosis.
Article in Fatigue : biomedicine, health & behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Fatigue is one of the most prevalent and disabling symptoms of multiple sclerosis (MS), frequently showing weak correlation with physical disability or MRI lesion burden. Central activation models link fatigue to dysfunction of brainstem arousal pathways, particularly the Ascending Reticular Activating System (ARAS). Because vertical saccades are generated in the mesencephalon and interact with these arousal networks, they may provide an objective marker of central fatigue. Objectives: To examine the relationship between vertical saccadic parameters and fatigue severity in MS, adjusting for cognitive impairment and affective symptoms. Results: Forty-four patients were included (61.4% women; mean age 49.0 ± 9.9 years; median EDSS 2.0). Fatigue severity was inversely associated with vertical saccadic peak velocity, most prominently for upward movements (r = -0.45, Conclusions: Higher fatigue severity was independently associated with slower upward vertical saccadic peak velocity, across all sensitivity analyses. These findings suggest that vertical saccadic dynamics may represent a promising objective correlate of central fatigue and support a pathophysiological link with mesencephalic arousal network dysfunction in MS.
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