Evidence map›Paper›PMID 42577774›Full record

ArticleFrontiers in drug discovery2026

Optimization of a malachite green-pyrophosphatase assay for the Zika virus RNA-dependent RNA polymerase and preliminary identification of natural product modulators.

Vanessa Aitken, Anthony F T Moore, Manuel Terrazas-López, Salvador Rodarte, Eda Koculi

Abstract read
In one paragraph

Article in Frontiers in drug discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vanessa AitkenDepartment of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, TX, United States.
Anthony F T MooreDepartment of Chemistry, University of Central Florida, Orlando, FL, United States.
Manuel Terrazas-LópezDepartment of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, TX, United States.
Salvador RodarteComputational Sciences Program, The University of Texas at El Paso, El Paso, TX, United States.
Eda KoculiDepartment of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, TX, United States.

Funding

Studies of Ribosome BiogenesisR01GM131062 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI KOCULI, EDA · 2019 to 2023
$1.7M
NIGMS NIH HHS R01 GM131062
6 · The paper itself

Abstract

The Zika virus (ZIKV) is an

Indexed as

digallic acidmalachite green assaypurpurogallinRNA-dependent RNA polymeraseZika virus

Identifiers

PMID42577774
PMCPMC13455045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.