ReviewRSC advances2026
Carrier-free self-assembled nanoparticles derived from traditional Chinese medicine active components: construction strategies and applications.
Review in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Active compounds derived from traditional Chinese medicine (TCM) hold considerable promise for drug development, owing to their natural origin and multi-target synergistic effects. However, their clinical translation has long been limited by poor aqueous solubility, low bioavailability, and inadequate targeting capacity. In recent years, carrier-free self-assembled nanomedicines have emerged as a promising strategy within the field of nano-enabled TCM. Driven by noncovalent interactions, such as hydrophobic forces, hydrogen bonding, and π-π stacking, these systems facilitate the spontaneous assembly of TCM-derived bioactive molecules into well-defined nanostructures. This approach can substantially improve drug loading efficiency, biocompatibility, and therapeutic synergy. This comprehensive review summarizes the underlying assembly mechanisms, key formulation parameters, and recent advances in the application of these nanostructures across antitumor, antibacterial, and anti-inflammatory therapies. It also discusses major challenges hindering large-scale production and clinical translation, including particle size control, stability, safety, and pharmacokinetic behavior. By integrating mechanistic insights with application outcomes and translational considerations, this comprehensive review aims to provide a comprehensive framework for the rational design of self-assembled TCM-based nanomedicines, thereby supporting the modernization of TCM and expanding its potential in innovative drug development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.