Evidence map›Paper›PMID 42577710›Full record

ArticleERJ open research2026

Integrated DNA methylome and transcriptome signatures of lung CD4

Camille M Moore, Shu-Yi Liao, Li Li, Jonathan Cardwell, Arunangshu Sarkar, Kristyn MacPhail, Margaret M Mroz, Christina Riley, Nancy W Lin, Elizabeth Davidson and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Camille M MooreDivision of Biostatistics and Bioinformatics, National Jewish Health, Denver, CO, USA.
Shu-Yi LiaoDepartment of Medicine, National Jewish Health, Denver, CO, USA.
Li LiDepartment of Medicine, National Jewish Health, Denver, CO, USA.
Jonathan CardwellDepartment of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Arunangshu SarkarDivision of Biostatistics and Bioinformatics, National Jewish Health, Denver, CO, USA.ORCID https://orcid.org/0000-0002-0648-4750
Kristyn MacPhailDepartment of Medicine, National Jewish Health, Denver, CO, USA.
Margaret M MrozDepartment of Medicine, National Jewish Health, Denver, CO, USA.
Christina RileyDepartment of Medicine, National Jewish Health, Denver, CO, USA.
Nancy W LinDepartment of Medicine, National Jewish Health, Denver, CO, USA.
Elizabeth DavidsonDepartment of Biomedical Informatics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Cheyret WoodDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID https://orcid.org/0000-0002-9418-4917
Clara I RestrepoDepartment of Medicine, National Jewish Health, Denver, CO, USA.
Ivana V YangDepartment of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Lisa A MaierDepartment of Medicine, National Jewish Health, Denver, CO, USA.ORCID https://orcid.org/0000-0001-6872-1769

Funding

Targeting early events in MUC5B-driven lung injury and fibrosisP01HL162607 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI David Albert Schwartz · 2023 to 2026
$12.4M
Subtyping COre for Research on the Etiology of Type 2 Diabetes (SCORE-T2D)U01DK140738 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Katherina Kechris-Mays, Leslie A Lange · 2024 to 2026
$7.1M
A Prospective Study of T cell Immune-phenotype and Disease Outcome in Pulmonary SarcoidosisR01HL136681 · NHLBI · NATIONAL JEWISH HEALTH · PI HAMZEH, NABEEL, KOTH, LAURA L · 2018 to 2021
$4.0M
Molecular Determinants of Usual Interstitial Pneumonia (UIP)R01HL158668 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI David Albert Schwartz, Ivana V Yang · 2022 to 2026
$3.5M
PRIDE Academy: Impact of Ancestry and Gender to omics of lung diseasesR25HL146166 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Matthew Wayne DeCamp, Sonia Castro Flores · 2019 to 2026
$3.4M
Genetic and epigenomic determinants of hearing loss in Hispanic populationsR01DC019642 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI SANTOS-CORTEZ, REGIE LYN PASTOR, YANG, IVANA V · 2021 to 2025
$3.4M
Predictive Models of Beryllium Sensitization and Chronic Beryllium DiseaseR01ES034767 · NIEHS · NATIONAL JEWISH HEALTH · PI Maneesh Bhargava, Li Li · 2023 to 2026
$3.2M
Molecular Characterization of Progressive Pulmonary SarcoidosisR01HL162955 · NHLBI · NATIONAL JEWISH HEALTH · PI Maneesh Bhargava, ELLIOTT D CROUSER · 2023 to 2026
$3.2M
Using Multi-Omics to Define Regulators and Drivers of Granulomatous Inflammation and Chronic Beryllium DiseaseR01ES033678 · NIEHS · NATIONAL JEWISH HEALTH · PI LISA A MAIER, Ivana V Yang · 2022 to 2026
$3.1M
Epigenetic Regulation of Immune Pathways in SarcoidosisR01HL140357 · NHLBI · NATIONAL JEWISH HEALTH · PI MAIER, LISA A, YANG, IVANA V · 2018 to 2021
$2.8M
Comprehensive Proteomic Classifier for the Molecular Characterization of Pulmonary SarcoidosisR01HL153613 · NHLBI · UNIVERSITY OF MINNESOTA · PI BHARGAVA, MANEESH, MAIER, LISA A · 2021 to 2024
$2.8M
Novel integrative approaches for disease phenotyping, utilizing radiomics in SarcoidosisR01HL142049 · NHLBI · NATIONAL JEWISH HEALTH · PI CARLSON, NICHOLE, FINGERLIN, TASHA E. · 2019 to 2022
$2.6M
NHLBI NIH HHS P01 HL162607NHLBI NIH HHS R01 HL136681NHLBI NIH HHS R01 HL140357NHLBI NIH HHS R01 HL142049NHLBI NIH HHS R01 HL153613NHLBI NIH HHS R01 HL158668NHLBI NIH HHS R01 HL162955NHLBI NIH HHS R25 HL146166NIDCD NIH HHS R01 DC019642NIDDK NIH HHS U01 DK140738NIEHS NIH HHS R01 ES023826NIEHS NIH HHS R01 ES033678NIEHS NIH HHS R01 ES034767
6 · The paper itself

Abstract

Rationale: Activated pulmonary CD4 Methods: Bronchoalveolar lavage (BAL) CD4 Measurements and main results: Using transcriptome-wide significance, differentially expressed (DE) transcripts were identified in participants with sarcoidosis (39), SarcNP (23) and SarcP (7), compared with controls. Using genome-wide significance, 37 CpGs and 47 regions were identified as differentially methylated (DM) in sarcoidosis participants, compared with controls. Focusing on DE genes, we identified DM CpGs in 11 genes associated with sarcoidosis, 3 with SarcNP and 7 with SarcP. In DIABLO, the first latent component distinguished cases and controls based on transcripts and CpGs associated with T-cell signalling, T-cell differentiation, apoptosis and epigenetic regulation. Among the DE/DM transcripts identified by integrative omic analysis and validated by single-cell RNA-seq is interleukin 18 receptor accessory protein ( Conclusions: Integrative methylome-transcriptome profiling of lung CD4

Identifiers

PMID42577710
PMCPMC13454880

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.