Evidence map›Paper›PMID 42577658›Full record

ArticleERJ open research2026

Inhaler mastery and retention after stepwise training in cognitively impaired older COPD.

Federico Lavorini, Alessandra Sorano, Carlo Fumagalli, Claudia Mannini, Giulia Fabietti, Giorgio Vitale, Ludovica Benuzzi, Raffaele Marfella, Niccolò Marchionni, Omar S Usmani

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Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Federico LavoriniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-3293-2123
Alessandra SoranoDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Carlo FumagalliDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.
Claudia ManniniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Giulia FabiettiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Giorgio VitaleDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Ludovica BenuzziDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Raffaele MarfellaDepartment of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.
Niccolò MarchionniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Omar S UsmaniNational Heart and Lung Institute, Imperial College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In older COPD patients with cognitive impairment, inhaler technique errors are common, but may be reduced by simplified designs and structured training. Methods: We conducted a prospective, crossover study with follow-up at 5±1 weeks in device-naïve COPD patients aged ≥70 years with moderate cognitive impairment (Mini Mental State Examination score 10-24). Physical function was assessed (Fried's Frailty Phenotype and Barthel Index). Participants demonstrated technique with a multidose dry powder inhaler (mDPI), a capsule-based DPI (cDPI), and a pressurised metered-dose inhaler (pMDI) after reading the patient information leaflet, then received a standardised stepwise training programme. Co-primary end-points were mastery after reading the patient information leaflet and after expert tuition. Secondary end-points included time to mastery, 1-month technique retention, and satisfaction (10-item Feeling of Satisfaction with Inhaler questionnaire). Results: 96 patients completed the study (mean age 79 years; 42% women; 66% pre-frail, 14% frail). After reading the patient information leaflet, correct technique was achieved by 29% with mDPI, 13% with cDPI, and 7% with pMDI. Errors were more frequent (p<0.001) with the pMDI (n=137) and cDPI (n=98) than with the mDPI (n=65). Training enabled all patients to achieve mastery, with shorter (p<0.001) times for the mDPI (3.1±1.1 min) than the cDPI (8.5±2.1 min) or pMDI (9.1±3.3 min). After 1 month, 85% maintained correct technique, higher (p<0.05) for the mDPI (97%) than pMDI (77%). Satisfaction scores favoured (p<0.01) the mDPI. Conclusions: Structured training allows older cognitively impaired COPD patients to master and retain inhaler technique. The mDPI was simpler, faster to learn, and better retained, supporting its use in geriatric COPD care.

Identifiers

PMID42577658
PMCPMC13454861

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