ReviewInternational journal of dentistry2026
Effectiveness and Safety of Pretreatment Analgesics and Anti-Inflammatory Drugs in Endodontic Pain Management: Overview of Systematic Reviews.
Review in International journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effectiveness and Safety of Pretreatment Analgesics and Anti-Inflammatory Drugs in Endodontic Pain Management: Overview of Systematic Reviews.International journal of dentistry · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Postoperative pain in endodontic treatment remains a significant challenge and concern for specialists. Despite advancements in treatment techniques, reports of postoperative pain due to trauma to the periapical tissues persist. The pretreatment anti-inflammatory drugs (nonsteroidal anti-inflammatory drugs [NSAIDs] and corticosteroids) and analgesic drugs (opioids and nonopioids) are a pharmacotherapeutic strategy employed for pain relief and inflammation control in endodontics. Objective: This overview of systematic reviews of randomized controlled trials (RCTs) synthesized the available evidence on the effectiveness and safety of pretreatment anti-inflammatory and analgesic drugs in pain management for patients undergoing endodontic treatment. Methods: The databases searched included the Cochrane Library, MEDLINE, EMBASE, Epistemonikos, Scopus, Web of Science, and Virtual Health Library, up to March 2023. Pairs of reviewers independently selected the studies, extracted the data, and assessed the methodological quality using the AMSTAR-2 (A MeaSurement Tool to Assess systematic Reviews 2) tool. Results: Fourteen systematic reviews that met the eligibility criteria were included, published between 2016 and 2022, involving between 3 and 27 primary studies that addressed pretreatment use of drugs. Six systematic reviews conducted meta-analyses and found that the pretreatment oral or parenteral corticosteroids reduced postoperative pain, compared with placebo, for 6, 12, and 24 h after nonsurgical endodontic treatment. NSAID systematic reviews have presented many conflicting results. Most reviews were of critically low quality, and data on adverse effects were poorly reported. Conclusion: Pretreatment corticosteroids appeared to be associated with more consistent reductions in postoperative pain among patients undergoing endodontic treatment. However, confidence in these findings is limited by substantial heterogeneity, the critically low methodological quality of most reviews, and poor reporting of adverse effects. Further high-quality RCTs are needed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.