Evidence map›Paper›PMID 42577593›Full record

SynthesisFrontiers in psychiatry2026

Immersive wearable virtual reality for autism: a systematic review of current evidence.

Chiara Failla, Roberta Minutoli, Paola Chilà, Germana Doria, Ileana Scarcella, Chiara Marraffa, Flavio Corpina, Gaia Roccaforte, Noemi Crifò, Anna Meduri and 2 more

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chiara FaillaInstitute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), Messina, Italy.
Roberta MinutoliInstitute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), Messina, Italy.
Paola ChilàInstitute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), Messina, Italy.
Germana DoriaInstitute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), Messina, Italy.
Ileana ScarcellaInstitute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), Messina, Italy.
Chiara MarraffaInstitute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), Messina, Italy.
Flavio CorpinaMulti-Specialist Clinical Institute for Orthopaedic Trauma Center (COT), Messina, Italy.
Gaia RoccaforteInstitute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), Messina, Italy.
Noemi CrifòInstitute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), Messina, Italy.
Anna MeduriInstitute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), Messina, Italy.
Giovanni PioggiaInstitute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), Messina, Italy.
Flavia MarinoInstitute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), Messina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Immersive and wearable virtual reality (VR) is an emerging technology with growing potential to support assessment and intervention ifor autistic people. The methodological heterogeneity of existing studies limits the interpretation and generalization of current evidence. Methods: A systematic review with a narrative synthesis was conducted in accordance with the PRISMA guidelines. Electronic searches were performed in PubMed, Scopus, IEEE Xplore, Web of Science, and Google Scholar, identifying studies published between 2015 and August 2025. Twenty-two studies investigating wearable and immersive VR interventions in children and adults with ASD met the eligibility criteria. Results: The included studies demonstrated that wearable VR interventions may improve social communication, joint attention, emotional regulation, daily living skills, executive functioning, and user engagement. Innovative technologies, including eye-tracking and artificial intelligence-based systems, also enabled objective assessment of gaze behaviour, social interaction, and physiological responses. Nevertheless, the evidence was characterized by considerable methodological heterogeneity, predominantly small sample sizes, limited use of randomized controlled designs, and scarce long-term follow-up, reducing the generalizability of the findings. Discussion: Wearable VR represents a promising tool for personalized assessment and intervention in ASD. Based on the current evidence, we propose a structured pre-intervention assessment integrating sensory, cognitive, emotional, and VR tolerance profiles to support individualized intervention planning. Future research should prioritize standardized outcome measures, rigorous study designs, and longitudinal investigations to strengthen the clinical translation of VR-based interventions in autism.

Indexed as

autism spectrum disorderhead-mounted displaysimmersive technologyvirtual realitywearable virtual reality

Identifiers

PMID42577593
PMCPMC13454810

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.