Lower Respiratory Microbiome Dysbiosis Is Associated With Poor Prognosis in Acute Severe Lower Respiratory Tract Infection.

Minghua Zhan, Hongbin Chen, Ziyao Li, Si Liu, Binghuai Lu, Zhang Wang, Hui Wang

Abstract read

In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Minghua ZhanDepartment of Clinical Laboratory Peking University People's Hospital Beijing China.ORCID https://orcid.org/0009-0000-1535-8222

Hongbin ChenDepartment of Clinical Laboratory Peking University People's Hospital Beijing China.

Ziyao LiLaboratory of Clinical Microbiology and Infectious Diseases, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine, Institute of Respiratory Medicine China-Japan Friendship Hospital Beijing China.

Si LiuDepartment of Clinical Laboratory Peking University People's Hospital Beijing China.

Binghuai LuLaboratory of Clinical Microbiology and Infectious Diseases, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine, Institute of Respiratory Medicine China-Japan Friendship Hospital Beijing China.

Zhang WangInstitute of Ecological Sciences School of Life Sciences South China Normal University Guangzhou Guangdong China.

Hui WangDepartment of Clinical Laboratory Peking University People's Hospital Beijing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute severe lower respiratory tract infections (asLRTIs) pose a significant clinical challenge, especially in critically ill patients, but the role of the lower respiratory tract microbiome (LRTM) remains unclear. This study aimed to characterize LRTM composition and host immune factors to identify prognostic features of clinical outcomes. The study included 53 asLRTI patients and 35 controls. Metagenomics, metabolomics, proteomics, and RNA sequencing were conducted, while analysis of similarities (ANOSIM) and Cox regression were performed for statistics. Clinical data, including pneumonia severity scores, were collected on BALF sampling, with a 100-day follow-up. LRTM samples were grouped into five clusters (C1-C5). Cluster C5 resembled controls, while others showed significantly lower diversity. LRTM composition correlated with prognosis, with higher pathogenic bacteria abundance linked to poorer outcomes. Cluster C3 was associated with poor prognosis and reduced survival. Metabolite analysis revealed elevated α-ketoisocaproic acid in asLRTIs and higher 10-nitrolinoleate in poor-prognosis patients. Immune responses varied across clusters, with distinct gene and cytokine expression patterns. Cluster C1, associated with

Indexed as

acute severe lower respiratory tract infectionsimmune responseslower respiratory tract microbiomemNGS

Identifiers

PMID42577546

DOI10.1002/mco2.70907

PMCPMC13454543

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