Evidence map›Paper›PMID 42577520›Full record

ReviewFrontiers in human neuroscience2026

Are gamifying exergames the future of intervention for people with dementia? Systematic review and meta-analysis.

Elena Papamichael, Irene-Chrysovalanto Themistocleous, Stelios Hadjisavvas, Christina Michailidou

Abstract readReview
In one paragraph

Review in Frontiers in human neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elena PapamichaelDepartment of Health Sciences, School of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus.
Irene-Chrysovalanto ThemistocleousDepartment of Health Sciences, School of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus.
Stelios HadjisavvasDepartment of Health Sciences, School of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus.
Christina MichailidouDepartment of Health Sciences, School of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Gamified exergaming has emerged as a promising approach for enhancing cognitive and motor function in older adults, yet its effectiveness in people with dementia remains unclear. Existing research has largely focused on individuals with mild cognitive impairment, leaving a gap in understanding how these interventions perform in populations with more advanced cognitive decline. Objective: The primary goal of this study was to systematically evaluate and quantify the effects of gamified exergaming on cognitive function. Secondary, to evaluate motor performance, and activities of daily living (ADL) in individuals with dementia compared with non-exergaming or standard care interventions. Methods: A systematic search of MEDLINE/PubMed, Cochrane CENTRAL, and EBSCO (2016-2026) identified randomized controlled trials involving exergaming interventions for people with dementia. Nine studies met the inclusion criteria. Risk of bias was assessed using the RoB2 tool. Meta-analyses were conducted using random-effects models, with outcomes synthesized for MoCA, MMSE, ADL, and motor function (SPPB). Results: A total of 717 participants were included. Exergaming produced a significant improvement in global cognition measured by the MoCA ( Conclusion: Gamified exergaming demonstrates a meaningful positive effect on global cognition in individuals with dementia, while evidence for motor and functional improvements remains inconclusive. The variability of intervention protocols and limited number of dementia-specific trials highlight the need for standardized, high-quality randomized studies. Exergaming represents a feasible and engaging therapeutic option that may complement traditional rehabilitation in dementia care.

Indexed as

activities of daily livingcognitive functiondementiaexergamingmotor function

Identifiers

PMID42577520
PMCPMC13454307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.