ArticleCirculation reports2026
Right Ventricular Diastolic Function Predicts Adverse Outcomes After Pulmonary Valve Replacement in Patients With Repaired Tetralogy of Fallot.
Article in Circulation reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The optimal timing of pulmonary valve replacement (PVR) in repaired tetralogy of Fallot (TOF) remains debated. We examined the influence of right ventricular (RV) diastolic dysfunction on post-PVR outcomes and investigated whether age ≥35 years at PVR is universally associated with adverse outcomes or represents a risk factor only in specific patient subgroups. Methods and Results: We reviewed 81 patients who underwent PVR for repaired TOF at Osaka University between 2002 and 2022. Adverse outcomes were defined as catheter ablation or pacemaker implantation for arrhythmia, or unplanned hospitalization for heart failure. RV diastolic dysfunction was defined as RV end-diastolic pressure ≥12 mmHg and/or a right atrial (RA) volume index ≥83 mL/m Conclusions: RV diastolic dysfunction was significantly associated with post-PVR clinical outcomes. Age ≥35 years at PVR was a significant risk factor only in patients with RV diastolic dysfunction, but not in those without, suggesting that advanced age alone does not uniformly confer increased risk.
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