SynthesisFrontiers in pediatrics2026
Recurrence rate and risk factors of recurrence after antiseizure medications withdrawal in children with epilepsy: a meta-analysis.
Synthesis in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Objective: This study aims to explore the recurrence rate and risk factors for recurrence after antiseizure medications withdrawal in children with epilepsy through a meta-analysis. Methods: Databases were searched up to May 8, 2025. Two reviewers independently screened the literature, extracted data, and assessed study quality. A meta-analysis was performed using Stata 15.0. Results: Nineteen studies involving 3,226 children were included. The pooled recurrence rate was 28% (95% CI: 23%-33%). Risk factors included female gender, focal seizure, history of febrile seizures, delayed development/intellectual disability, symptomatic etiology, abnormal electroencephalogram (EEG) after withdrawal. Conclusion: Multiple factors increase recurrence risk after antiseizure medications withdrawal in children, supporting individualized clinical decision-making.
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