ArticleFrontiers in immunology2026
Environment shapes gut microbiome and determines susceptibility to DSS-colitis in
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Inflammatory bowel disease (IBD) is characterized by marked clinical heterogeneity, reflecting complex interactions between host genetics, environmental exposures, and the gut microbiome. Although over 300 genetic risk loci have been identified, these account for only a fraction of disease variance, highlighting the importance of gene-environment interactions. ADAM-like Decysin-1 (ADAMDEC1) is a gastrointestinal-restricted metalloprotease implicated in mucosal repair and immune regulation, with reduced expression reported in IBD. While Methods: To dissect genetic and environmental contributions to colitis severity, C57BL/6J wild-type (WT) and Results: Environmental factors exerted a stronger influence than genotype on gut microbiome composition. WT mice displayed consistent inflammatory and transcriptional responses to DSS across environments, whereas Conclusion: These findings demonstrate that loss of
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