ArticleFrontiers in pediatrics2026
Choroidal microcirculation in pediatric craniopharyngioma: postoperative alterations in choroidal thickness.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To evaluate choroidal microcirculation using choroidal thickness (CTh) in pediatric patients with surgically treated adamantinomatous craniopharyngioma (CP) and to identify clinical and tumor-related factors associated with CTh. Methods: This cross-sectional, prospective, observational study included 60 eyes of 31 children with histopathologically confirmed CP and 78 eyes of 39 age- and sex-matched healthy controls. Comprehensive ophthalmological examination and spectral-domain optical coherence tomography (SD-OCT) were performed in all participants. CTh was manually measured at five locations: subfoveal (SFCTh), 1500 μm superior, inferior, nasal, and temporal to the fovea in both eyes. Tumor characteristics and demographic data were collected and analyzed for associations with CTh. Results: CTh was significantly thinner in the CP group compared to controls at all locations except 1500 μm superior to the fovea. The mean subfoveal CTh was 333.13 μm in the CP group and 370.13 μm in the control group ( Conclusion: Pediatric patients with CP show significantly reduced CTh in multiple locations. Place of birth, and specific tumor characteristics such as cavernous sinus infiltration were influenced by CTh. These findings highlight the complex interplay between tumor characteristics and ocular microvascular changes in pediatric patients with CP.
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