ArticleFrontiers in immunology2026
Transcriptomic profiling reveals selective attenuation of interferon-associated inflammatory signaling and induction of metallothioneins by a zinc-containing oral rinse.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Oral stromal and epithelial cells contribute to mucosal inflammation through cytokine-induced chemokine production. Essential oil-containing mouth rinses are widely used as adjuncts to oral hygiene, but whether zinc-containing formulations directly modulate host inflammatory signaling remains unclear. This study investigated the effects of a zinc-containing Listerine Methods: Primary human gingival fibroblasts were stimulated with IL-1β/TNF-α in the presence or absence of Listerine Results: IL-1β/TNF-α induced a broad inflammatory transcriptional program characterized by chemokines, NF-κB-associated mediators, and interferon-associated genes. Listerine Conclusion: These findings identify a previously unrecognized host-modulatory activity of a zinc-containing Listerine
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