ArticleFrontiers in medicine2026
Early multi-system physiological biomarkers of bronchopulmonary dysplasia in preterm infants: a matched case-control study based on bedside monitoring.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To identify early multi-system physiological biomarkers that can be obtained at the bedside prior to the formal diagnosis of bronchopulmonary dysplasia (BPD). Methods: We conducted a single-center retrospective 1:1 matched case-control study enrolling preterm infants of less than 32 weeks' gestational age admitted to the neonatal intensive care unit (NICU) of our institution between June 2022 and June 2025. Infants with confirmed BPD were assigned to the BPD group, and non-BPD controls were matched 1:1 by gestational age and birth weight. Baseline characteristics, bedside monitoring parameters, blood gas indices, and quantitative echocardiographic features were compared between the two groups. Candidate early variables associated with BPD were first screened using LASSO-penalized logistic regression, after which representative indicators from each physiological domain were selected to construct a multivariate logistic regression model. Results: A total of 50 infants were included in each group, and no significant differences in baseline or maternal perinatal characteristics were found between the two groups (all Conclusion: An early six-variable physiological profile integrating IMV, peak FiO
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