ArticleFrontiers in nutrition2026
Nutritional-metabolic indicators do not independently predict AVF thrombosis after adjustment for surgical frequency: a retrospective cohort study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Arteriovenous fistula (AVF) thrombosis is a leading cause of vascular access failure in hemodialysis patients. Although nutritional status is often hypothesized to influence thrombotic risk, most previous studies have not accounted for surgical burdens such as repeated surgical procedures. This study assessed whether common nutritional and metabolic markers are independently associated with AVF thrombosis after adjustment for surgical frequency. Methods: This retrospective cohort study included 783 patients who underwent AVF creation between January 2017 and October 2024. Nutritional and metabolic markers were defined using standard formulas. Missing data were handled using multiple imputation. Candidate predictors were identified through univariate analysis ( Results: Among 783 patients (median follow-up 34 months), 96 (12.3%) developed AVF thrombosis. Cumulative surgical burden was the strongest independent risk marker (hazard ratio [HR] = 1.44, 95% CI: 1.28-1.62, Conclusion: After accounting for surgical frequency, conventional nutritional and metabolic indices did not demonstrate independent associations with AVF thrombosis in the present study. Patients with high cumulative surgical burden should be recognized as a high-risk population warranting enhanced surveillance, and optimizing blood pressure control should remain a clinical priority.
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