Evidence map›Paper›PMID 42576991›Full record

ArticleMaterials today. Bio2026

A tumor microenvironment-responsive calcium overload nanoplatform inducing PANoptosis for enhanced cancer immunotherapy.

Aiyang Tong, Yang Zhou, Yang Ding, Yuelin Zhao, Changna Han, Linlin Wei, Jian Zhao

Abstract read
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aiyang TongDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, China.
Yang ZhouMedical Oncology Department of Gastrointestinal Cancer, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute, Cancer Hospital of China Medical University, China.
Yang DingMedical Oncology Department of Gastrointestinal Cancer, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute, Cancer Hospital of China Medical University, China.
Yuelin ZhaoDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, China.
Changna HanDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, China.
Linlin WeiDepartment of Radiotherapy, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute, Cancer Hospital of China Medical University, China.
Jian ZhaoDepartment of Colorectal Surgery, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute, Cancer Hospital of China Medical University, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PANoptosis, a newly characterized form of inflammatory programmed cell death that integrates multiple cell death modalities, offers distinct advantages in both potent tumor cell killing and activation of antitumor immunity. However, strategies that can effectively induce PANoptosis in tumor cells remain scarce. Herein, we constructed a tumor microenvironment-responsive nanoplatform (HA-MnO

Indexed as

Calcium overloadImmunogenic cell deathPANoptosisReactive oxygen speciesTumor microenvironment-responsive nanoplatform

Identifiers

PMID42576991
PMCPMC13453507

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.