ArticleResearch and practice in thrombosis and haemostasis2026
Arterial shear rate determines the structure and mechanical properties of whole-blood clots.
Article in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Open sesame: unlocking mechanics of clots formed under flow.Research and practice in thrombosis and haemostasis · 2026Article
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Authors and funding
6 authors.
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Abstract
Background: Arterial thrombosis arises under high shear conditions and is a leading cause of ischemic stroke and myocardial infarction. The local hemodynamic environment during the formation of the thrombus influences its final composition, which in turn influences its mechanical characteristics and the associated risk of embolization. However, how arterial shear rates determine the local mechanical properties, structure, and composition of clots remains poorly understood. Objectives: This study investigated how physiological and pathologic arterial shear rates shape blood clot composition, formation dynamics, and regional mechanical properties in a microfluidic flow model. Methods: We used a microfluidic flow model that allows real-time imaging of blood clot formation under controlled arterial shear rates (300/s, 1000/s, and 3500/s). We visualized platelets and fibrin deposition using confocal microscopy and quantified composition-dependent spatial heterogeneities in clot stiffness with microindentation. Results: Pathologically high (3500/s) arterial shear rates promoted more rapid platelet aggregation and the formation of taller platelet-rich clots. Fibrin deposition started after ∼6 minutes in all shear conditions and coincided with platelet aggregate stabilization at higher shear rates. Microindentation revealed that platelet- and fibrin-rich regions were significantly stiffer than red blood cell-rich regions. Clots formed at 3500/s had a >3-fold higher average stiffness than those formed at 300/s, reflecting their higher platelet content. Conclusion: This study demonstrates that arterial shear rate governs clot growth and composition, translating into shear-dependent microscale mechanical properties. These findings provide new mechanistic insights into clot properties that are relevant for clot stability and vulnerability to embolization.
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