Evidence map›Paper›PMID 42576792›Full record

ArticleTransboundary and emerging diseases2026

Identification and Characterization of Scutavirus testudinidalpha3 Infection in Captive Elongated Tortoises (Indotestudo elongata).

Han-Yang Wang, Shih-Hsuan Liu, Wei-Hsiang Huang, Hui-Wen Chang, Chain-Ren Jeng, Chiu-Hung Cheng, Pao-Jung Wang, Yen-Chen Chang

Abstract read
In one paragraph

Article in Transboundary and emerging diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Han-Yang WangGraduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan, ntu.edu.tw.ORCID https://orcid.org/0009-0009-3338-1018
Shih-Hsuan LiuTaipei Zoo, Taipei, Taiwan.
Wei-Hsiang HuangGraduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan, ntu.edu.tw.ORCID https://orcid.org/0000-0002-0098-0278
Hui-Wen ChangGraduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan, ntu.edu.tw.ORCID https://orcid.org/0000-0001-8877-1886
Chain-Ren JengGraduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan, ntu.edu.tw.ORCID https://orcid.org/0000-0003-3941-6276
Chiu-Hung ChengTaipei Zoo, Taipei, Taiwan.
Pao-Jung WangTaipei Zoo, Taipei, Taiwan.
Yen-Chen ChangGraduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan, ntu.edu.tw.ORCID https://orcid.org/0000-0002-4971-4237

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Scutavirus testudinidalpha3, formerly Testudinid alphaherpesvirus 3 or testudinid herpesvirus (TeHV)-3, is a highly contagious herpesvirus that has been reported in multiple testudinid species, causing acute stomatitis-rhinitis complex in affected animals or establishing latent infections in surviving individuals. This study investigated an outbreak of S. testudinidalpha3 infection in 17 elongated tortoises (Indotestudo elongata) housed exclusively in an outdoor zoo enclosure in Taiwan in March, 2022. The affected tortoises exhibited nasal and ocular discharge and diphtheroid plaques on the oral mucosa. Despite prompt isolation and supportive treatment, 14 individuals succumbed. Necropsy and histopathologic examination revealed severe necrosis with inflammation, characterized by eosinophilic intranuclear inclusion bodies and occasional syncytial cells in multiple organs. Conventional polymerase chain reaction (PCR) and in situ hybridization (ISH) confirmed S. testudinidalpha3 infection. DNA polymerase (DNApol) gene sequences were identical among all individuals and shared 97.86% nucleotide similarity with the German 4295/7R strain. Furthermore, the full-length sequence of glycoprotein B (gB), a potential virulence factor in herpesviruses, showed 99.9% identity with the Switzerland CH6883/03 strain, classifying this isolate as belonging to the genogroup B, known for its high pathogenicity. This report documents the first confirmed case of S. testudinidalpha3 infection in elongated tortoises.

Indexed as

HerpesviridaeHerpesviridae InfectionsTurtlesAnimalsAnimals, ZooDisease OutbreaksPhylogenyTaiwanglycoprotein BIndotestudo elongatain situ hybridizationScutavirus testudinidalpha3

Identifiers

PMID42576792
PMCPMC13458721

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.