Evidence map›Paper›PMID 42576618›Full record

ArticleThe New phytologist2026

The miR167-ARF8 module coordinates stamen-pistil development and fruit set in tomato.

Nave Man, Naama Teboul, Amir Bahu, Moritz Friesch, Alon Israeli, Tzahi Arazi, Bettina Hause, Naomi Ori

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The New phytologist, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nave ManThe Institute of Plant Sciences and Genetics in Agriculture, The Robert H. Smith Faculty of Agriculture, Food and Environment, the Hebrew University, PO Box 12, Rehovot, 7610001, Israel.ORCID https://orcid.org/0000-0002-1996-266X
Naama TeboulThe Institute of Plant Sciences and Genetics in Agriculture, The Robert H. Smith Faculty of Agriculture, Food and Environment, the Hebrew University, PO Box 12, Rehovot, 7610001, Israel.ORCID https://orcid.org/0000-0002-9091-2585
Amir BahuThe Institute of Plant Sciences and Genetics in Agriculture, The Robert H. Smith Faculty of Agriculture, Food and Environment, the Hebrew University, PO Box 12, Rehovot, 7610001, Israel.ORCID https://orcid.org/0009-0008-9703-8799
Moritz FrieschDepartment of Cell and Metabolic Biology, Leibniz Institute of Plant Biochemistry, Halle, 06120, Germany.ORCID https://orcid.org/0009-0007-0272-022X
Alon IsraeliThe Institute of Plant Sciences and Genetics in Agriculture, The Robert H. Smith Faculty of Agriculture, Food and Environment, the Hebrew University, PO Box 12, Rehovot, 7610001, Israel.ORCID https://orcid.org/0000-0002-3339-2042
Tzahi AraziInstitute of Plant Sciences, Agricultural Research Organization-Volcani Institute, HaMaccabbim Road 68, PO Box 15159, Rishon LeZion, 7505101, Israel.ORCID https://orcid.org/0000-0002-9821-2604
Bettina HauseDepartment of Cell and Metabolic Biology, Leibniz Institute of Plant Biochemistry, Halle, 06120, Germany.ORCID https://orcid.org/0000-0001-9697-4990
Naomi OriThe Institute of Plant Sciences and Genetics in Agriculture, The Robert H. Smith Faculty of Agriculture, Food and Environment, the Hebrew University, PO Box 12, Rehovot, 7610001, Israel.ORCID https://orcid.org/0000-0002-5129-5369

Funding

Deutsche Forschungsgemeinschaft HA2655/17-2Israel Science Foundation 248-19Israel Science Foundation 511-25Ministry of Agriculture and Rural Development 12-01-0051
6 · The paper itself

Abstract

Auxin is an important regulator of reproductive development. The families of the AUXIN RESPONSE FACTOR (ARF) genes, important components of the auxin signal, have expanded in flowering plants. Tomato (Solanum lycopersicum) has two copies of ARF8, which are negatively regulated by miR167. Here, we investigated the involvement of this expanded SlmiR167-SlARF8 module in flower development. Mutants were generated in 5 SlmiR167 and 2 SlARF8 genes, and flower development and fruit set were characterized in mutant combinations. We show that the SlmiR167-SlARF8 module regulates flower-organ development and fruit set. The two SlARF8 paralogs are found to have both overlapping and distinct roles. They additively affect stigma position by oppositely affecting stamen and pistil growth, while SlARF8B has evolved a unique role in the inhibition of anther dehiscence. Loss of SlARF8B in the Slmir167a background uncovers a unique reproductive syndrome of fast, early, fertilization-independent fruit set and increased yield under cold stress, mediated by the deregulation of SlARF8A. These results demonstrate how gene duplication within the miR167-ARF8 module enables fine-tuning of auxin signaling to achieve coordinated, robust reproductive development, with implications for the control of fruit set in tomato.

Indexed as

FlowersFruitMicroRNAsPlant ProteinsSolanum lycopersicumGene Expression Regulation, PlantGenes, PlantMutationPhenotypeMicroRNAsPlant Proteinsanther dehiscenceARF8flower developmentgene familiesmiR167parthenocarpystigma positiontomato

Identifiers

PMID42576618
PMCPMC13583376

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.